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Sigma-Aldrich

2-Chloro-3-(trifluoromethyl)pyridine

97%

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About This Item

Empirical Formula (Hill Notation):
C6H3ClF3N
CAS Number:
65753-47-1
Molecular Weight:
181.54
EC Number:
424-520-6
MDL number:
MFCD00042223
UNSPSC Code:
12352100
PubChem Substance ID:
24870592
NACRES:
NA.22

assay

97%

form

solid

mp

36-40 °C (lit.)

SMILES string

FC(F)(F)c1cccnc1Cl

InChI

1S/C6H3ClF3N/c7-5-4(6(8,9)10)2-1-3-11-5/h1-3H

InChI key

RXATZPCCMYMPME-UHFFFAOYSA-N

General description

2-Chloro-3-(trifluoromethyl)pyridine is a trifluoromethyl-substituted pyridine derivative.

Application

2-Chloro-3-(trifluoromethyl)pyridine may be used in the preparation of 5,5′-bis(trifluoromethyl)-2,2′-bipyridine, via modified Ullmann reaction.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1B - STOT RE 1

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

Certificates of Analysis (COA)

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Modified Ullmann coupling of 2-chloro-3-trifluoromethylpyridine.
Munavalli S, et al.
Journal of Fluorine Chemistry, 73(1), 1-6 (1995)
Trifluoromethyl-Substituted Pyridines Through Displacement of Iodine by in situ Generated (Trifluoromethyl) copper.
Cottet F and Schlosser M.
European Journal of Organic Chemistry, 2, 327-330 (2002)

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