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402494

Sigma-Aldrich

Phenylarsine oxide

technical grade

Synonym(s):

Arzene, Oxophenylarsine, PAO

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About This Item

Empirical Formula (Hill Notation):
C6H5AsO
CAS Number:
Molecular Weight:
168.02
Beilstein/REAXYS Number:
2935227
EC Number:
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:

grade

technical grade

reaction suitability

reagent type: catalyst
core: arsenic

SMILES string

O=[As]c1ccccc1

InChI

1S/C6H5AsO/c8-7-6-4-2-1-3-5-6/h1-5H

InChI key

BQVCCPGCDUSGOE-UHFFFAOYSA-N

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Biochem/physiol Actions

Phenylarsine oxide inhibits internalization of cell surface receptors; inhibits tyrosine phosphatases, with no effect on tyrosine kinase. Metabolic poison.

Other Notes

Contains varying amounts of polymer

replaced by

Product No.
Description
Pricing

pictograms

Skull and crossbonesEnvironment

signalword

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


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Anne-Christine Schmidt et al.
Journal of chromatography. A, 1218(2), 280-285 (2010-12-24)
A separation method for a mixture of eight sulfur-containing peptides and proteins characterized by a wide molar mass (1-18.4 kDa) and pI range (4.5-10.7) was developed onto a monolithic phenyl phase. Based on the first optimization steps that revealed an
M S Song et al.
Neuroscience, 178, 181-188 (2011-01-26)
A number of recent studies have indicated that accumulation of β amyloid (Aβ) peptides within neurons is an early event which may trigger degeneration of neurons and subsequent development of Alzheimer's disease (AD) pathology. However, very little is known about
Anne-Christine Schmidt et al.
Journal of mass spectrometry : JMS, 47(8), 949-961 (2012-08-18)
Phenylarsenic-substituted cysteine-containing peptides and proteins were completely differentiated from their unbound original forms by the coupling of reversed phase liquid chromatography with electrospray ionization mass spectrometry. The analysis of biomolecules possessing structure-stabilizing disulfide bridges after reduction provides new insights into
Biyun Ni et al.
Clinical cancer research : an official journal of the American Association for Cancer Research, 18(1), 140-151 (2011-11-04)
Bax and Bak are regarded as key mediators for cytochrome c (Cyt c) release and apoptosis. Loss of Bax or Bak is often reported in human cancers and renders resistance of these cancerous cells to chemotherapy. Here, we investigated that
Bingbing Li et al.
Plant physiology, 159(2), 671-681 (2012-04-25)
Protein tyrosine phosphatases (PTPases) have long been thought to be activated by reductants and deactivated by oxidants, owing to the presence of a crucial sulfhydryl group in their catalytic centers. In this article, we report the purification and characterization of

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