394882

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide

>97%

• Synonym(s): MTBSTFA
• Linear Formula: CF₃CON(CH₃)Si(CH₃)₂C(CH₃)₃
• CAS Number: 77377-52-7
• Molecular Weight: 241.33
• Beilstein/REAXYS Number: 3606546
• MDL number: MFCD00009671
• UNSPSC Code: 12352001
• PubChem Substance ID: 24864624
• NACRES: NA.22

Properties

• grade: derivatization grade
• Quality Level: 200
• assay: >97%
• form: liquid
• refractive index: n20/D 1.402 (lit.)
• bp: 172-175 °C (lit.)
• density: 1.036 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: CN(C(=O)C(F)(F)F)[Si](C)(C)C(C)(C)C
• InChI: 1S/C9H18F3NOSi/c1-8(2,3)15(5,6)13(4)7(14)9(10,11)12/h1-6H3
• InChI key: QRKUHYFDBWGLHJ-UHFFFAOYSA-N

Description

General description

N-tert-Butyldimethylsilyl-N-methyltrifluoroacetamide is a highly reactive silylating reagent commonly used for silyation of carboxylic acids, alcohols, amines, and thiols. It is also used as a protection, deprotection reagent.

Application

N-tert-butyldimethylsilyl-N-methyltrifluoroacetamide (MTBSTFA) can be used:

• As a derivatizing agent in the GC-MS analysis of hydroxylated fluorenes and in the GC analysis of amino acids.
• As an efficient silylating agent for different alcohols, thiols, phenols, carboxylic acids, amines, and amides.
• To functionalize multi-walled carbon nanotubes (MWCNTs) with polar groups.

MTBSTFA is reportedly much less moisture-sensitive than other silylating reagents used for GLC derivatization.

Safety Information

• pictograms: GHS02
• signalword: Warning
• hcodes: H226
• pcodes: P210 - P233 - P240 - P241 - P242 - P243
• Hazard Classifications: Flam. Liq. 3
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 113.0 °F - closed cup
• flash_point_c: 45 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter