371130

1,4-Diisocyanatobutane

97.0%

• Synonym(s): Tetramethylene diisocyanate
• Linear Formula: OCN(CH₂)₄NCO
• CAS Number: 4538-37-8
• Molecular Weight: 140.14
• Beilstein/REAXYS Number: 1756894
• MDL number: MFCD00075559
• UNSPSC Code: 12162002
• PubChem Substance ID: 24863093
• NACRES: NA.23

Properties

• assay: 97.0%
• form: liquid
• bp: 102-104 °C/14 mmHg (lit.)
• density: 1.105 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: O=C=NCCCCN=C=O
• InChI: 1S/C6H8N2O2/c9-5-7-3-1-2-4-8-6-10/h1-4H2
• InChI key: OVBFMUAFNIIQAL-UHFFFAOYSA-N

Description

General description

1,4-Diisocyanatobutane is a highly reactive compound with two isocyanate (-NCO) groups separated by a butane chain. It can undergo reactions such as urethane formation, crosslinking, and chain extension. It is widely used as a building block to synthesize polyurethane-based materials with excellent flexibility, impact resistance, and mechanical properties, making them useful in tissue engineering, contact lenses, biocompatible coatings, adhesives, foams, elastomers, and sealants.

Application

1,4-Diisocyanatobutanecan be used in the following fields:

Tissue engineering -As a precursor to synthesize polyurethane composites which can be used as 3D scaffolds for tissue engineering,

Contact lenses- As a cross-linking agent to prepare inorganic-organic hydrogel contact lenses for high refractive index ocular refractive correction biomaterial,

Controlled drug delivery- As a chain extender to synthesize segmented polyurethanes for redox-sensitive controlled drug release systems.

Safety Information

• pictograms: GHS08,GHS07
• signalword: Danger
• hcodes: H302 + H312 + H332,H315,H317,H319,H334,H335
• pcodes: P261 - P264 - P280 - P301 + P312 - P302 + P352 + P312 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
• target_organs: Respiratory system
• Storage Class: 10 - Combustible liquids
• wgk_germany: WGK 3
• flash_point_f: 222.8 °F - closed cup
• flash_point_c: 106 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter