4-Diphenylmethoxy-1-methylpiperidine hydrochloride

Name: 4-Diphenylmethoxy-1-methylpiperidine hydrochloride
Brand: ALDRICH
Price: 85.5 USD
Availability: InStock

95%

Synonym(s):

4-Diphenylmethoxy-1-methylpiperidine, Diphenylpyraline hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₉H₂₃NO · HCl

CAS Number:

132-18-3

Molecular Weight:

317.85

NACRES:

NA.22

PubChem Substance ID:

24856946

UNSPSC Code:

12352100

EC Number:

205-049-3

MDL number:

MFCD00012835

Assay:

95%

Key Documents

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Quality Level

100

assay

95%

mp

203-205 °C (lit.)

functional group

ether, phenyl

SMILES string

Cl[H].CN1CCC(CC1)OC(c2ccccc2)c3ccccc3

InChI

1S/C19H23NO.ClH/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17;/h2-11,18-19H,12-15H2,1H3;1H

InChI key

LPRLDRXGWKXRMQ-UHFFFAOYSA-N

Gene Information

human ... HRH1(3269)

Related Categories

Heterocyclic Building Blocks

Chemical Building Blocks

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1 of 4

This Item	H8885	768944	792152
Sigma-Aldrich 280550 4-Diphenylmethoxy-1-methylpiperidine hydrochloride	Sigma-Aldrich H8885 Hydroxyzine dihydrochloride	Sigma-Aldrich 768944 4-Pentyn-1-amine hydrochloride	Sigma-Aldrich 792152 4-Methylpiperidine solution
assay 95%	assay ≥97%	assay ≥97.0% (GC), 97.0-103.0%	assay ≥95.5%
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
mp 203-205 °C (lit.)	mp -	mp -	mp -
functional group ether	functional group -	functional group amine	functional group -
Gene Information human ... HRH1(3269)	Gene Information human ... HRH1(3269)	Gene Information -	Gene Information -

General description

4-Diphenylmethoxy-1-methylpiperidine hydrochloride is also referred as diphenylpyraline hydrochloride (DPP), is a first-generation antihistamine[1].

Application

4-Diphenylmethoxy-1-methylpiperidine hydrochloride was used as a pharmacotherapy for Parkinson′s disease[2].

pictograms

GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Diphenylpyraline-responsive parkinsonism in cerebrotendinous xanthomatosis: long-term follow up of three patients.

T Ohno et al.

Journal of the neurological sciences, 182(2), 95-97 (2001-01-04)

A long-term follow-up study was made of three patients with cerebrotendinous xanthomatosis (CTX) associated with parkinsonism, two of whom were siblings. Besides typical CTX symptoms, all three patients showed severe parkinsonism. This observation has been rarely reported in CTX. The

Simultaneous estimation of phenylpropanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrups by LC.

M Vasudevan et al.

Journal of pharmaceutical and biomedical analysis, 24(1), 25-31 (2000-12-07)

A simple, precise and accurate HPLC method was developed for the simultaneous estimation of phenyl-propanolamine HCl, guaiphenesin and diphenylpyraline HCl in syrup. The method was carried out on a Shimpak C8 column with a mobile phase consisting of acetonitrile-triethylamine (pH

[Parkinsonism associated with cerebrotendinous xanthomatosis].

N Shibata et al.

Rinsho shinkeigaku = Clinical neurology, 30(9), 978-984 (1990-09-01)

Two sibling cases of cerebrotendinous xanthomatosis with parkinsonism were reported. One was a woman of 39 years old, and another was her sister of 36 years old. In both cases, febrile convulsion appeared on 1.5 year old, and mental deterioration

Effects of H1 antihistamines on canine nasal vascular and airway resistances.

M A Lung et al.

Rhinology, 25(2), 95-100 (1987-06-01)

The effects of three commonly used H1 antihistamines on the nasal vascular and airway resistances were studied in the dog. Promethazine hydrochloride decreased nasal vascular resistance but increased nasal airway resistance in a dose-dependent manner. Diphenylpyraline hydrochloride in low doses

Diphenylpyraline, a histamine H1 receptor antagonist, has psychostimulant properties.

Gennady B Lapa et al.

European journal of pharmacology, 506(3), 237-240 (2005-01-04)

Diphenylpyraline hydrochloride (DPP) is used clinically as an antihistamine drug, but its neurobiological effects are not completely understood. Voltammetry and microdialysis were used to investigate potential actions of DPP on the dopamine system. Voltammetric monitoring of dopamine signals in mouse

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Global Trade Item Number

SKU	GTIN
280550-10G	04061833045626

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