Macroautophagy can promote cellular survival or death depending on the cellular context and its extent. We hypothesized that autophagy induction would synergize with a therapeutic agent targeting the autophagic cargo. To test this hypothesis, we treated breast cancer MDA-MB-231 cells
Ribonucleotide reductase (RNR) plays a critical role in catalyzing the biosynthesis and maintaining the intracellular concentration of 4 deoxyribonucleoside triphosphates (dNTPs). Unbalanced or deficient dNTP pools cause serious genotoxic consequences. Autophagy is the process by which cytoplasmic constituents are degraded
International archives of occupational and environmental health, 63(2), 133-138 (1991-01-01)
A physiologically based mathematical model is described for the human inhalation pharmacokinetics of 1,1,2-trichloro-1,2,2-trifluoroethane (FC113). Physiological parameters for the model are derived from the scientific literature. Partition coefficients are determined from in vitro measurements. Predictions of the resulting model for
American Industrial Hygiene Association journal, 51(7), 395-401 (1990-07-01)
Results obtained using the Fourier transform infrared spectrophotometer (FTIR) and the Miniature Infrared Analyzer (MIRAN) for samples of workplace air containing trichloroethylene (TCE) were evaluated through comparison with results obtained when using a gas chromatography (GC). The effects of instrument
Toxicology and industrial health, 6(3-4), 493-498 (1990-05-01)
The interaction of Freon 113 (1,1,2-trichloro-1,2,2-trifluoroethane) and hypoxia on the heart conduction system was studied using electrocardiogram monitoring of isolated perfused rat hearts. Freon 113 (0.2 mM) alone elicited significant atrioventricular conduction delay (p less than 0.05) and heart rate
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
