265152

2,6-Difluorobenzaldehyde

98%

• Linear Formula: F₂C₆H₃CHO
• CAS Number: 437-81-0
• Molecular Weight: 142.10
• Beilstein/REAXYS Number: 1935273
• MDL number: MFCD00010293
• UNSPSC Code: 12352100
• PubChem Substance ID: 24856057
• NACRES: NA.22

Properties

• assay: 98%
• form: liquid
• refractive index: n20/D 1.502 (lit.)
• bp: 82-84 °C/15 mmHg (lit.)
• mp: 15-17 °C (lit.)
• density: 1.317 g/mL at 25 °C (lit.)
• storage temp.: 2-8°C
• SMILES string: Fc1cccc(F)c1C=O
• InChI: 1S/C7H4F2O/c8-6-2-1-3-7(9)5(6)4-10/h1-4H
• InChI key: SOWRUJSGHKNOKN-UHFFFAOYSA-N

Description

Application

2,6-Difluorobenzaldehyde can be used as a reactant to synthesize:

• 5-Cyano-6-(2,6-difluorophenyl)-5,6-dihydro-2-thiouracil via one-pot cyclocondensation reaction with ethyl cyanoacetate and thiourea.
• 1-(2,6-Difluorobenzyl)-2-(2,6-difluorophenyl)-benzimidazole by reacting with 1,2-phenylenediamine in the presence of a catalytic amount of p-toluenesulfonic acid.
• (3E)-4-(2,6-Difluorophenyl)-3-buten-2-one by Wittig olefination reaction with acetylmethylidenetriphenyl phosphorane.
• Methyl 4-fluorobenzo[b]thiophene-2-carboxylate by treating with methyl thioglycolate in the presence of K₂CO₃.

Safety Information

• pictograms: GHS05
• signalword: Danger
• hcodes: H314,H412
• pcodes: P273 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363
• Hazard Classifications: Aquatic Chronic 3 - Eye Dam. 1 - Skin Corr. 1C
• Storage Class: 8A - Combustible corrosive hazardous materials
• wgk_germany: WGK 2
• flash_point_f: 180.5 °F - closed cup
• flash_point_c: 82.5 °C - closed cup
• ppe: Eyeshields, Gloves, type ABEK (EN14387) respirator filter