261483

N,N-Dimethylacetamide dimethyl acetal

90%

• Synonym(s): 1,1-Dimethoxy-N,N-dimethylethylamine
• Linear Formula: CH₃C(OCH₃)₂N(CH₃)₂
• CAS Number: 18871-66-4
• Molecular Weight: 133.19
• Beilstein/REAXYS Number: 1420865
• MDL number: MFCD00008476
• UNSPSC Code: 12352100
• PubChem Substance ID: 24855813
• NACRES: NA.22

Properties

• Quality Level: 200
• assay: 90%
• form: liquid
• refractive index: n20/D 1.411 (lit.)
• bp: 118 °C (lit.)
• density: 0.911 g/mL at 25 °C (lit.)
• functional group: amine; ether
• SMILES string: COC(C)(OC)N(C)C
• InChI: 1S/C6H15NO2/c1-6(8-4,9-5)7(2)3/h1-5H3
• InChI key: FBZVZUSVGKOWHG-UHFFFAOYSA-N

Description

General description

Claisen type reaction of N,N-dimethylacetamide dimethyl acetal using optically active trans-3-penten-2-ol as substrate has been investigated[1].

Application

N,N-Dimethylacetamide dimethyl acetal has been used as:

• one carbon inserting synthon in preparation of pyrimido[1,2-a][1,3,5]triazin-6-ones[2]
• reagent for the synthesis of amides[3], diacylamines[4] and heterocycles[5][6]

Safety Information

• pictograms: GHS02,GHS06,GHS08
• signalword: Danger
• hcodes: H225,H302,H311 + H331,H315,H319,H335,H371
• pcodes: P210 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P311 - P308 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 2 - STOT SE 3
• target_organs: Eyes,Central nervous system, Respiratory system
• Storage Class: 3 - Flammable liquids
• wgk_germany: WGK 3
• flash_point_f: 46.4 °F - closed cup
• flash_point_c: 8 °C - closed cup
• ppe: Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter