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24880

5-Chloro-7-iodo-8-quinolinol

≥95.0% (HPLC)

Synonym(s):

5-Chloro-8-hydroxy-7-iodoquinoline, Clioquinol, Iodochlorhydroxyquin

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100 g

Available to ship TODAYfromMILWAUKEE

$252.00
500 g
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$1,070.00

About This Item

Empirical Formula (Hill Notation):
C9H5ClINO
CAS Number:
130-26-7
Molecular Weight:
305.50
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
57648095
EC Number:
204-984-4
Beilstein/REAXYS Number:
153637
MDL number:
MFCD00006787
Assay:
≥95.0% (HPLC)
Form:
powder

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Quality Level

200

assay

≥95.0% (HPLC)

form

powder

solubility

dioxane: soluble 0.5 g/10 mL, clear, faintly yellow to yellow

functional group

chloro, iodo

SMILES string

Oc1c(I)cc(Cl)c2cccnc12

InChI

1S/C9H5ClINO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H

InChI key

QCDFBFJGMNKBDO-UHFFFAOYSA-N

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This Item
D6460033931C47000
5-Chloro-7-iodo-8-quinolinol ≥95.0% (HPLC)

Sigma-Aldrich

24880

5-Chloro-7-iodo-8-quinolinol

5,7-Dichloro-8-quinolinol 99%

Sigma-Aldrich

D64600

5,7-Dichloro-8-quinolinol

Clioquinol VETRANAL®, analytical standard

Supelco

33931

Clioquinol

5-Chloro-8-quinolinol 95%

Sigma-Aldrich

C47000

5-Chloro-8-quinolinol

assay

≥95.0% (HPLC)

assay

99%

assay

-

assay

95%

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

solubility

dioxane: soluble 0.5 g/10 mL, clear, faintly yellow to yellow

solubility

-

solubility

-

solubility

-

form

powder

form

powder

form

-

form

crystals

functional group

chloro, iodo

functional group

-

functional group

-

functional group

-

General description

5-Chloro-7-iodo-8-quinolinol is an antibiotic with metal-binding properties and exhibits anticancer activity in vitro and in vivo[1]. 5-Chloro-7-iodo-8-quinolinol, its glucuronide and sulfate in serum, urine and milk has been quantitated by gas chromatography[2].

Application

5-Chloro-7-iodo-8-quinolinol has been used in analysis of intracellular free zinc ions with the FluoZin-3 probes using fluorescence microscopy[1].

pictograms

Skull and crossbones
GHS06

signalword

Danger

Hazard Classifications

Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificates of Analysis (COA)

Lot/Batch Number
BCCJ9965
BCBW9276
BCBT1809
BCBR8937V
BCBN5847V

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A gas chromatographic determination method of 5-chloro-7-iodo-8-quinolinol and its conjugates in biological fluids.
C Chen et al.
Chemical & pharmaceutical bulletin, 24(1), 97-101 (1976-01-01)
Peter J Crouch et al.
Journal of neurochemistry, 119(1), 220-230 (2011-07-30)
Impaired metal ion homeostasis causes synaptic dysfunction and treatments for Alzheimer's disease (AD) that target metal ions have therefore been developed. The leading compound in this class of therapeutic, PBT2, improved cognition in a clinical trial with AD patients. The
Jie Geng et al.
Advanced healthcare materials, 1(3), 332-336 (2012-11-28)
Metal ions play important roles in amyloid aggregation and neurotoxicity. Metal-ion chelation therapy has been used in clinical trials for Alzheimer's disease (AD) treatment. However, clinical trial studies have shown that long-term use of metal chelator can cause adverse side
Lin W Hung et al.
Future medicinal chemistry, 4(8), 955-969 (2012-06-02)
In 1906, Alois Alzheimer first characterized the disease that bears his name. Despite intensive research, which has led to a better understanding of the pathology, there is no effective treatment for this disease. Of the drugs approved by the US
A D Schimmer
Current cancer drug targets, 11(3), 325-331 (2011-01-21)
Clioquinol (5-chloro-7-iodo-quinolin-8-ol) was used in the 1950's-1970's as an oral anti-parasitic agent. More recently, studies have demonstrated that Clioquinol displays preclinical efficacy in the treatment of malignancy. Its anti-cancer activity relates, at least in part, to its ability to inhibit
View All Related Papers

Global Trade Item Number

SKUGTIN
24880-500G04061832242064
24880-100G04061825928340

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