202509

Poly(ethylene glycol) methyl ether

average M_n 2,000, methoxy, hydroxyl

• Synonym(s): Polyethylene glycol, Methoxy poly(ethylene glycol), Polyethylene glycol monomethyl ether, mPEG
• Linear Formula: CH₃(OCH₂CH₂)_nOH
• CAS Number: 9004-74-4
• MDL number: MFCD00084416
• UNSPSC Code: 12162002
• PubChem Substance ID: 24852095
• NACRES: NA.23

Properties

• product name: Poly(ethylene glycol) methyl ether, average M_n ~2,000
• vapor density: >1 (vs air)
• vapor pressure: 0.05 mmHg ( 20 °C)
• form: flakes (or pellets)
• mol wt: average M_n ~2,000
• viscosity: 54.6 cSt(210 °F)(lit.)
• transition temp: T_m 52 °C
• functional group: hydroxyl
• InChI: 1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3
• InChI key: XNWFRZJHXBZDAG-UHFFFAOYSA-N

Description

General description

It is a Polyethylene glycol (PEG) macromer with a reactive chain end consisting of methyl ether. Etherification of the PEG chain ends can be undertaken in basic conditions by reacting it with alkyl halides. mPEG can undergo cross linking to form hydrogels; polymerization can be initiated by redox reaction or free radical initiator.

Application

Poly(ethylene glycol) methyl ether-attached dendrimers can be used as carriers for anticancer drugs. This novel drug carrier has a biocompatible surface and an interior for the encapsulation of drugs.

It can be used as a pore-forming agent in the preparation of ultrafiltration membranes which are used in the removal of macromolecules.

It can also be used as a starting material in the preparation of a biodegradable amphiphilic copolymer of poly(L-alanine) with mPEG.

Features and Benefits

Inserting poly(ethylene glycol) methyl ether (mPEG) side chain enhances the hydrophilicity and flexibility of the polymer matrix.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 1
• flash_point_f: 359.6 °F - closed cup
• flash_point_c: 182 °C - closed cup
• ppe: Eyeshields, Gloves