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151564

Sigma-Aldrich

5-Hydroxydopamine hydrochloride

98%

Synonym(s):

3,4,5-Trihydroxyphenethylamine hydrochloride

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About This Item

Linear Formula:
(HO)3C6H2CH2CH2NH2·HCl
CAS Number:
5720-26-3
Molecular Weight:
205.64
EC Number:
227-223-8
MDL number:
MFCD00012899
UNSPSC Code:
12352100
PubChem Substance ID:
24849145
NACRES:
NA.22

assay

98%

form

powder

mp

218-220 °C (lit.)

functional group

amine

SMILES string

Cl.NCCc1cc(O)c(O)c(O)c1

InChI

1S/C8H11NO3.ClH/c9-2-1-5-3-6(10)8(12)7(11)4-5;/h3-4,10-12H,1-2,9H2;1H

InChI key

WSZSSLCEWCKAKU-UHFFFAOYSA-N

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Application

5-Hydroxydopamine hydrochloride was used in the preparation of hydrogen peroxide, superoxide radical and hydroxyl radical[1].

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000239865
0000239863
0000239864
0000227167
0000227167

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Elizabeth Mazzio et al.
Neuroscience letters, 337(2), 77-80 (2003-01-16)
The neuropathology of Parkinson's disease (PD) involves a reduction of endogenous antioxidant enzyme systems, heightened oxidative stress and mitochondrial aberrations in the region of the substantia nigra. Similarly, neurotoxins commonly used to investigate PD pathology include 6-hydroxydopamine (6-OHDA), a powerful
J C Linder et al.
Neurochemistry international, 26(2), 195-202 (1995-02-01)
The dopaminergic projection from the substantia nigra to the neostriatum is vulnerable to several neurotoxins including 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), amphetamine, and 5-hydroxydopamine. We have treated rats or mice with these agents and examined various regions of their brains with a combination
H P Liu et al.
Journal fur Hirnforschung, 38(1), 107-117 (1997-01-01)
The present ultrastructural study investigated the innervation of the guinea pig pancreas, with special emphasis on the pancreatic ganglia and the sympathetic and parasympathetic boutons/terminals. The pancreatic ganglion cells, ensheathed in a thin layer of connective tissue, showed typical features
K Jellinger et al.
Journal of neural transmission. Supplementum, 46, 297-314 (1995-01-01)
The presence of 5-Hydroxydopamine (5-OHDA) and 6-Hydroxydopamine (6-OHDA) in the urine of parkinsonian patients on levodopa medication was reported by Andrew et al. (1993). To answer the question about the putative relevance of 6-OHDA endogenously formed in the brain for
F Vandenabeele et al.
Archives of histology and cytology, 64(1), 1-16 (2001-04-20)
Ultrastructural studies of the synovial membrane were performed on tissue samples obtained from the human lumbar facet joint. Ultrastructural changes in synoviocytes were studied after loading synovial samples with 5-hydroxydopamine (5-OHDA) in an oxygenated Krebs' solution, prior to fixation. Synoviocytes
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