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109975

Sigma-Aldrich

1,2-Epoxybutane

99%

Synonym(s):

α-Butylene oxide, 1,2-Butylene oxide, 1-Butene oxide, Ethyloxirane

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About This Item

Empirical Formula (Hill Notation):
C4H8O
CAS Number:
106-88-7
Molecular Weight:
72.11
Beilstein/REAXYS Number:
102411
EC Number:
203-438-2
MDL number:
MFCD00005153
UNSPSC Code:
12162002
PubChem Substance ID:
24846950
NACRES:
NA.23

vapor density

2.2 (vs air)

vapor pressure

140 mmHg ( 20 °C)

assay

99%

autoignition temp.

698 °F

expl. lim.

19 %

refractive index

n20/D 1.384 (lit.)

bp

63 °C (lit.)

density

0.829 g/mL at 25 °C (lit.)

SMILES string

CCC1CO1

InChI

1S/C4H8O/c1-2-4-3-5-4/h4H,2-3H2,1H3

InChI key

RBACIKXCRWGCBB-UHFFFAOYSA-N

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Application

1,2-Epoxybutane can be used:
  • As a monomer to synthesize novel initiators via ring-opening polymerization. These initiators can be used to prepare complex macromolecules such as grafted polyamides.
  • To functionalize polyethyleneimine which is used in the synthesis of oxidation-stable adsorbents for CO2 capture.

Features and Benefits

  • High polymerizability
  • Low susceptibility to transfer reaction
  • Ease of handling

signalword

Danger

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Flam. Liq. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

5.0 °F - closed cup

flash_point_c

-15 °C - closed cup

ppe

Eyeshields, Faceshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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T Nakamura et al.
Biochemical and biophysical research communications, 180(1), 124-130 (1991-10-15)
Halohydrin hydrogen-halide-lyase, which catalyzes the interconversion of halohydrins to epoxides, purified from a recombinant E. coli was found to catalyze the transformation of 1,2-epoxybutane into beta-hydroxyvaleronitrile in the presence of cyanide. Chloride inhibited competitively the formation of beta-hydroxyvaleronitrile. The enzyme
M Katz et al.
Journal of environmental pathology and toxicology, 3(5-6), 171-187 (1980-06-01)
Nitrosopiperidine, sodium nitrite and 1,2 epoxybutane were tested in the Ames agar incorporation assay in an attempt to establish exact criteria for detecting the activity of these weak mutagens. As regards minimum concentrations it was determined that at 500 microgram
Hong Yuan Sun et al.
Carbohydrate research, 344(15), 1999-2004 (2009-08-26)
A new soluble cyclodextrin derivative 6-O-(2-hydroxybutyl)-beta-cyclodextrin (6-HB-beta-CD) was prepared. Its molecular binding and recognition ability were investigated with the comparison of beta-cyclodextrin (beta-CD), 2-O-(2-hydroxypropyl)-beta-cyclodextrin (2-HP-beta-CD), 6-O-(2-hydroxypropyl)-beta-cyclodextrin (6-HP-beta-CD), and 2-O-(2-hydroxybutyl)-beta-cyclodextrin (2-HB-beta-CD). The relationship between the complex stability constants and the possible
A M Rossi et al.
Teratogenesis, carcinogenesis, and mutagenesis, 3(1), 75-87 (1983-01-01)
In vivo and in vitro methodologies that have employed the yeast Schizosaccharomyces pombe as genetic indicator have been utilized to investigate the mutagenicity of two trichloroethylene (TCE) samples of pure and technical grade. Mutagenicity assays were also performed on two
Stuart J Khan et al.
Analytical chemistry, 78(8), 2608-2616 (2006-04-18)
Trace concentrations of small soluble epoxides are suspected byproducts of drinking water ozonation. However, adequate characterization of epoxide formation is currently limited by the lack of suitable analytical methods to target these chemicals in dilute, but complex aqueous solutions. One
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