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UGT1A5

UDP glucuronosyltransferase 1 family, polypeptide A5

Synonyms:
UDPGT, UDPGT 1-5, UGT1E
Species:
Human UGT1A5 (54579), Mouse Ugt1a5 (394433), Rat Ugt1a5 (574523), Zebrafish ugt1a5 (100384897)
UniProtKB ID:
P35504
Gene ID:
  • Human(54579) Summary: This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. [provided by RefSeq, Jul 2008]
  • Mouse(394433) UDP glucuronosyltransferase 1 family, polypeptide A5
  • Rat(574523) UDP glucuronosyltransferase 1 family, polypeptide A5
  • Zebrafish(100384897) UDP glucuronosyltransferase 1 family, polypeptide A5

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