TNFSF11
tumor necrosis factor (ligand) superfamily, member 11
Synonyms:
CD254, ODF, OPGL, OPTB2, RANKL, TRANCE, hRANKL2, sOdf
Species:
Human TNFSF11 (8600), Mouse Tnfsf11 (21943), Rat Tnfsf11 (117516), domestic guinea pig Tnfsf11 (100713226), dog TNFSF11 (609418), cow TNFSF11 (513836), naked mole-rat Tnfsf11 (101696350), chicken TNFSF11 (428067), Zebrafish tnfsf11 (100331628)
UniProtKB ID:
Gene ID:
- Human(8600) Summary: This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008]
- Mouse(21943) tumor necrosis factor (ligand) superfamily, member 11
- Rat(117516) tumor necrosis factor (ligand) superfamily, member 11
- domestic guinea pig(100713226) tumor necrosis factor (ligand) superfamily, member 11
- dog(609418) tumor necrosis factor (ligand) superfamily, member 11
- cow(513836) tumor necrosis factor (ligand) superfamily, member 11
- naked mole-rat(101696350) tumor necrosis factor (ligand) superfamily, member 11
- chicken(428067) tumor necrosis factor (ligand) superfamily, member 11
- Zebrafish(100331628) tumor necrosis factor (ligand) superfamily, member 11
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TNFSF11 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-TNFSF11 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Monoclonal Anti-TRANCE antibody produced in mouse, clone 70525, purified immunoglobulin, lyophilized powder,
Species Reactivity
human
Application
immunohistochemistry
Anti-RANKL/TNFSF11 Antibody, clone 1H17 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, human, monkey, porcine
Application
affinity binding assay
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-RANKL Antibody, clone 6A12.1, clone 6A12.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Proteins
Product Number
Description
Species
sRank Ligand from rat, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Species
rat
sRANKL human, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture,
Species
human
RANK Ligand/TRANCE human, >90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder,
Species
human
Soluble RANK Ligand (sRANKL) Protein, Recombinant human, The recombinant human sRANKL protein is produced in E. Coli.,
Species
human
RANK Ligand from mouse, ≥98% (SDS-PAGE), recombinant, expressed in E. coli, lyophilized powder, suitable for cell culture,
Species
mouse
esiRNA
Product Number
Description
Species