TIRAP
toll-interleukin 1 receptor (TIR) domain containing adaptor protein
Synonyms:
BACTS1, Mal, MyD88-2, wyatt
Species:
Human TIRAP (114609), Mouse Tirap (117149), Rat Tirap (680127), sheep TIRAP (101118490), naked mole-rat Tirap (101715320), Zebrafish tirap (403148), cow TIRAP (531079), domestic cat TIRAP (101088688), domestic guinea pig Tirap (100732763), chicken TIRAP (419715)
UniProtKB ID:
Gene ID:
- Human(114609) Summary: The innate immune system recognizes microbial pathogens through Toll-like receptors (TLRs), which identify pathogen-associated molecular patterns. Different TLRs recognize different pathogen-associated molecular patterns and all TLRs have a Toll-interleukin 1 receptor (TIR) domain, which is responsible for signal transduction. The protein encoded by this gene is a TIR adaptor protein involved in the TLR4 signaling pathway of the immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which then results in cytokine secretion and the inflammatory response. Alternative splicing of this gene results in several transcript variants; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]
- Mouse(117149) toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
- Rat(680127) toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
- sheep(101118490) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- naked mole-rat(101715320) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- Zebrafish(403148) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- cow(531079) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- domestic cat(101088688) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- domestic guinea pig(100732763) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- chicken(419715) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
- dog(609544) toll-interleukin 1 receptor (TIR) domain containing adaptor protein
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-TIRAP (ab1) antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-TIRAP (AB2) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-TIRAP (AB1) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-TIRAP antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
immunohistochemistry
Anti-TIRAP antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot