STARD6
StAR-related lipid transfer (START) domain containing 6
Synonyms:
Species:
Human STARD6 (147323), Mouse Stard6 (170461), Rat Stard6 (291527), dog STARD6 (476193), domestic cat STARD6 (101096360), naked mole-rat Stard6 (101708461), domestic guinea pig Stard6 (100734647), sheep STARD6 (101114232), cow STARD6 (532195)
UniProtKB ID:
Gene ID:
- Human(147323) Summary: Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD6 (Soccio et al., 2002 [PubMed 12011452]
- Mouse(170461) StAR-related lipid transfer (START) domain containing 6
- Rat(291527) StAR-related lipid transfer (START) domain containing 6
- dog(476193) StAR-related lipid transfer (START) domain containing 6
- domestic cat(101096360) StAR-related lipid transfer (START) domain containing 6
- naked mole-rat(101708461) StAR-related lipid transfer (START) domain containing 6
- domestic guinea pig(100734647) StAR-related lipid transfer (START) domain containing 6
- sheep(101114232) StAR-related lipid transfer (START) domain containing 6
- cow(532195) StAR-related lipid transfer (START) domain containing 6
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