SF3A1
splicing factor 3a, subunit 1, 120kDa
Synonyms:
PRP21, PRPF21, SAP114, SF3A120
Species:
Human SF3A1 (10291), Mouse Sf3a1 (67465), Rat Sf3a1 (305479), naked mole-rat Sf3a1 (101716117), domestic guinea pig Sf3a1 (100712689), Zebrafish sf3a1 (796388), dog SF3A1 (477538), sheep SF3A1 (101110452), chicken SF3A1 (427717), Horse SF3A1 (100058749) ...More
UniProtKB ID:
Gene ID:
- Human(10291) Summary: This gene encodes subunit 1 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 1 belongs to the SURP protein family; named for the SURP (also called SWAP or Suppressor-of-White-APricot) motifs that are thought to mediate RNA binding. Subunit 1 has tandemly repeated SURP motifs in its amino-terminal half while its carboxy-terminal half contains a proline-rich region and a ubiquitin-like domain. Binding studies with truncated subunit 1 derivatives demonstrated that the two SURP motifs are necessary for binding to subunit 3 while contacts with subunit 2 may occur through sequences carboxy-terminal to the SURP motifs. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(67465) splicing factor 3a, subunit 1
- Rat(305479) splicing factor 3a, subunit 1
- naked mole-rat(101716117) splicing factor 3a, subunit 1, 120kDa
- domestic guinea pig(100712689) splicing factor 3a, subunit 1, 120kDa
- Zebrafish(796388) splicing factor 3a, subunit 1
- dog(477538) splicing factor 3a, subunit 1, 120kDa
- sheep(101110452) splicing factor 3a, subunit 1, 120kDa
- chicken(427717) splicing factor 3a, subunit 1, 120kDa
- Horse(100058749) splicing factor 3a, subunit 1, 120kDa
- domestic cat(101090805) splicing factor 3a, subunit 1, 120kDa
- cow(504381) splicing factor 3a, subunit 1, 120kDa
- Domestic Rabbit(100337770) splicing factor 3a, subunit 1, 120kDa
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-SF3A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human, mouse, rat
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-SF3A1 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot