PSME2
proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
Synonyms:
PA28B, PA28beta, REGbeta
Species:
Human PSME2 (5721), Mouse Psme2 (19188), Rat Psme2 (29614), cow PSME2 (509857), domestic guinea pig Psme2 (100734557), dog PSME2 (480258), domestic cat PSME2 (101100476), Zebrafish psme2 (30647), sheep PSME2 (100135691), naked mole-rat Psme2 (101702988)
UniProtKB ID:
Gene ID:
- Human(5721) Summary: The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. The immunoproteasome contains an alternate regulator, referred to as the 11S regulator or PA28, that replaces the 19S regulator. Three subunits (alpha, beta and gamma) of the 11S regulator have been identified. This gene encodes the beta subunit of the 11S regulator, one of the two 11S subunits that is induced by gamma-interferon. Three beta and three alpha subunits combine to form a heterohexameric ring. Six pseudogenes have been identified on chromosomes 4, 5, 8, 10 and 13. [provided by RefSeq, Jul 2008]
- Mouse(19188) proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
- Rat(29614) proteasome (prosome, macropain) activator subunit 2
- cow(509857) proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
- domestic guinea pig(100734557) proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
- dog(480258) proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
- domestic cat(101100476) proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
- Zebrafish(30647) proteasome activator subunit 2
- sheep(100135691) proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
- naked mole-rat(101702988) proteasome (prosome, macropain) activator subunit 2 (PA28 beta)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PSME2 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Monoclonal Anti-PSME2 antibody produced in mouse, clone 1G4, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot
Monoclonal Anti-PSME2 antibody produced in mouse, clone 3F11-1A3, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
Anti-PSME2 antibody produced in goat, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-PSME2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot