PRKCI
protein kinase C, iota
Synonyms:
DXS1179E, PKCI, nPKC-iota
Species:
Human PRKCI (5584), Mouse Prkci (18759), Rat Prkci (84006), domestic guinea pig Prkci (100731983), naked mole-rat Prkci (101697279), sheep PRKCI (101118322), Horse PRKCI (100063737), cow PRKCI (528478), dog PRKCI (478686), domestic cat PRKCI (101087000) ...More
UniProtKB ID:
Gene ID:
- Human(5584) Summary: This gene encodes a member of the protein kinase C (PKC) family of serine/threonine protein kinases. The PKC family comprises at least eight members, which are differentially expressed and are involved in a wide variety of cellular processes. This protein kinase is calcium-independent and phospholipid-dependent. It is not activated by phorbolesters or diacylglycerol. This kinase can be recruited to vesicle tubular clusters (VTCs) by direct interaction with the small GTPase RAB2, where this kinase phosphorylates glyceraldehyde-3-phosphate dehydrogenase (GAPD/GAPDH) and plays a role in microtubule dynamics in the early secretory pathway. This kinase is found to be necessary for BCL-ABL-mediated resistance to drug-induced apoptosis and therefore protects leukemia cells against drug-induced apoptosis. There is a single exon pseudogene mapped on chromosome X. [provided by RefSeq, Jul 2008]
- Mouse(18759) protein kinase C, iota
- Rat(84006) protein kinase C, iota
- domestic guinea pig(100731983) protein kinase C, iota
- naked mole-rat(101697279) protein kinase C, iota
- sheep(101118322) protein kinase C, iota
- Horse(100063737) protein kinase C, iota
- cow(528478) protein kinase C, iota
- dog(478686) protein kinase C, iota
- domestic cat(101087000) protein kinase C, iota
- chicken(424991) protein kinase C, iota
- Zebrafish(117507) protein kinase C, iota
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Small Molecule - Agonist
Product Number
Description
Species
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-PRKCI antibody produced in mouse, clone 1G11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
immunofluorescence
western blot
ANTI-PKC IOTA(N-TERMINAL) antibody produced in rabbit, IgG fraction of antiserum, buffered aqueous solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-PRKCI antibody produced in rabbit, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
ANTI-PRKCI antibody produced in mouse, clone 1C10, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Monoclonal Anti-PRKCI, (N-terminal) antibody produced in mouse, clone 3A7, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
PKC iota Recombinant Human Protein, Active, 10 µg, Active, N-terminal His6-tagged, recombinant full-length human PKC iota. For use in Kinase Assays.,
Species
human
PKCι, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human