PCDHGB4
protocadherin gamma subfamily B, 4
Synonyms:
CDH20, FIB2, PCDH-GAMMA-B4
Species:
Human PCDHGB4 (8641), Mouse Pcdhgb4 (93701), dog PCDHGB4 (607598), domestic guinea pig Pcdhgb4 (100721092), sheep PCDHGB4 (101105911), domestic cat PCDHGB4 (101099175), cow PCDHGB4 (532241)
UniProtKB ID:
Gene ID:
- Human(8641) Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. This particular family member is expressed in fibroblasts and is thought to play a role in wound healing in response to injury. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
- Mouse(93701) protocadherin gamma subfamily B, 4
- dog(607598) protocadherin gamma subfamily B, 4
- domestic guinea pig(100721092) protocadherin gamma subfamily B, 4
- sheep(101105911) protocadherin gamma subfamily B, 4
- domestic cat(101099175) protocadherin gamma subfamily B, 4
- cow(532241) protocadherin gamma subfamily B, 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-PCDHGB4 (34-45) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot
Anti-PCDHGB4 (130-141) antibody produced in rabbit, IgG fraction of antiserum,
Species Reactivity
human
Application
western blot