PCDHGA11
protocadherin gamma subfamily A, 11
Synonyms:
PCDH-GAMMA-A11
Species:
Human PCDHGA11 (56105), Mouse Pcdhga11 (93723), Rat Pcdhga11 (252897), domestic guinea pig Pcdhga11 (100723028), dog PCDHGA11 (487185), sheep PCDHGA11 (101105077), cow PCDHGA11 (101904103), domestic cat PCDHGA11 (101100441)
UniProtKB ID:
Gene ID:
- Human(56105) Summary: This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]
- Mouse(93723) protocadherin gamma subfamily A, 11
- Rat(252897) protocadherin gamma subfamily A, 11
- domestic guinea pig(100723028) protocadherin gamma subfamily A, 11
- dog(487185) protocadherin gamma subfamily A, 11
- sheep(101105077) protocadherin gamma subfamily A, 11
- cow(101904103) protocadherin gamma subfamily A, 11
- domestic cat(101100441) protocadherin gamma subfamily A, 11
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