NTAN1
N-terminal asparagine amidase
Synonyms:
PNAA, PNAD
Species:
Human NTAN1 (123803), Mouse Ntan1 (18203), Rat Ntan1 (360462), chicken NTAN1 (768445), dog NTAN1 (609485), domestic guinea pig Ntan1 (100716021), naked mole-rat Ntan1 (101726114), domestic cat NTAN1 (101080602), sheep NTAN1 (101113380), cow NTAN1 (505869)
UniProtKB ID:
Gene ID:
- Human(123803) Summary: The protein encoded by this gene functions in a step-wise process of protein degradation through the N-end rule pathway. This protein acts as a tertiary destabilizing enzyme that deamidates N-terminal L-Asn residues on proteins to produce N-terminal L-Asp. L-Asp substrates are subsequently conjugated to L-Arg, which is recognized by specific E3 ubiquitin ligases and targeted to the proteasome. Pseudogenes of this gene are located on the long arms of chromosomes 8, 10 and 12. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
- Mouse(18203) N-terminal Asn amidase
- Rat(360462) N-terminal asparagine amidase
- chicken(768445) N-terminal asparagine amidase
- dog(609485) N-terminal asparagine amidase
- domestic guinea pig(100716021) N-terminal asparagine amidase
- naked mole-rat(101726114) N-terminal asparagine amidase
- domestic cat(101080602) N-terminal asparagine amidase
- sheep(101113380) N-terminal asparagine amidase
- cow(505869) N-terminal asparagine amidase
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