MAP3K3
mitogen-activated protein kinase kinase kinase 3
Synonyms:
MAPKKK3, MEKK3
Species:
Human MAP3K3 (4215), Mouse Map3k3 (26406), Rat Map3k3 (303604), cow MAP3K3 (508943), Horse MAP3K3 (100064751), naked mole-rat Map3k3 (101704335), domestic guinea pig Map3k3 (100731994), sheep MAP3K3 (101122537), domestic cat MAP3K3 (101083633), dog MAP3K3 (480481) ...More
UniProtKB ID:
Gene ID:
- Human(4215) Summary: This gene product is a 626-amino acid polypeptide that is 96.5% identical to mouse Mekk3. Its catalytic domain is closely related to those of several other kinases, including mouse Mekk2, tobacco NPK, and yeast Ste11. Northern blot analysis revealed a 4.6-kb transcript that appears to be ubiquitously expressed. This protein directly regulates the stress-activated protein kinase (SAPK) and extracellular signal-regulated protein kinase (ERK) pathways by activating SEK and MEK1/2 respectively; it does not regulate the p38 pathway. In cotransfection assays, it enhanced transcription from a nuclear factor kappa-B (NFKB)-dependent reporter gene, consistent with a role in the SAPK pathway. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
- Mouse(26406) mitogen-activated protein kinase kinase kinase 3
- Rat(303604) mitogen activated protein kinase kinase kinase 3
- cow(508943) mitogen-activated protein kinase kinase kinase 3
- Horse(100064751) mitogen-activated protein kinase kinase kinase 3
- naked mole-rat(101704335) mitogen-activated protein kinase kinase kinase 3
- domestic guinea pig(100731994) mitogen-activated protein kinase kinase kinase 3
- sheep(101122537) mitogen-activated protein kinase kinase kinase 3
- domestic cat(101083633) mitogen-activated protein kinase kinase kinase 3
- dog(480481) mitogen-activated protein kinase kinase kinase 3
- chicken(419954) mitogen-activated protein kinase kinase kinase 3
- Zebrafish(560211) mitogen-activated protein kinase kinase kinase 3
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Map3K3 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
Anti-MAP3K3 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
proximity ligation assay
western blot
western blot
Anti-MAP3K3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-MAP3K3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
Anti-MAP3K3 antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Proteins
Product Number
Description
Species
MEKK3, active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in baculovirus infected Sf9 cells, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human