LCP2
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
Synonyms:
SLP-76, SLP76
Species:
Human LCP2 (3937), Mouse Lcp2 (16822), Rat Lcp2 (155918), dog LCP2 (489126), domestic cat LCP2 (101096877), domestic guinea pig Lcp2 (100718602), fruit fly Lcp2 (35818), chicken LCP2 (395438), sheep LCP2 (101105277), cow LCP2 (513244) ...More
UniProtKB ID:
Gene ID:
- Human(3937) Summary: SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. [provided by RefSeq, Jul 2008]
- Mouse(16822) lymphocyte cytosolic protein 2
- Rat(155918) lymphocyte cytosolic protein 2
- dog(489126) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- domestic cat(101096877) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- domestic guinea pig(100718602) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- fruit fly(35818) Larval cuticle protein 2
- chicken(395438) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- sheep(101105277) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- cow(513244) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- Horse(100059274) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- Domestic Rabbit(100339465) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
- naked mole-rat(101705208) lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-phospho-SLP-76 (pTyr128) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-LCP2 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Anti-LCP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-LCP2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
esiRNA
Product Number
Description
Species