FIG4
FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
Synonyms:
ALS11, CMT4J, KIAA0274, SAC3, YVS, dJ249I4.1
Species:
Human FIG4 (9896), Mouse Fig4 (103199), Rat Fig4 (309855), Zebrafish fig4 (100334605), domestic cat FIG4 (101080288), sheep FIG4 (101113245), cow FIG4 (534118), Horse FIG4 (100066727), naked mole-rat Fig4 (101713458), Zebrafish fig4 (100329711) ...More
UniProtKB ID:
Gene ID:
- Human(9896) Summary: The protein encoded by this gene belongs to the SAC domain-containing protein gene family. The SAC domain, approximately 400 amino acids in length and consisting of seven conserved motifs, has been shown to possess phosphoinositide phosphatase activity. The yeast homolog, Sac1p, is involved in the regulation of various phosphoinositides, and affects diverse cellular functions such as actin cytoskeleton organization, Golgi function, and maintenance of vacuole morphology. Membrane-bound phosphoinositides function as signaling molecules and play a key role in vesicle trafficking in eukaryotic cells. Mutations in this gene have been associated with Charcot-Marie-Tooth disease, type 4J. [provided by RefSeq, Jul 2008]
- Mouse(103199) FIG4 homolog (S. cerevisiae)
- Rat(309855) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- Zebrafish(100334605) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- domestic cat(101080288) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- sheep(101113245) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- cow(534118) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- Horse(100066727) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- naked mole-rat(101713458) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- Zebrafish(100329711) FIG4 homolog
- chicken(421762) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
- dog(475023) FIG4 homolog, SAC1 lipid phosphatase domain containing (S. cerevisiae)
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