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MilliporeSigma

F8

coagulation factor VIII, procoagulant component

Synonyms:
AHF, DXS1253E, F8B, F8C, FVIII, HEMA
Species:
Human F8 (2157), Mouse F8 (14069), Rat F8 (302470), naked mole-rat F8 (101725450), domestic guinea pig F8 (100720831), Zebrafish f8 (100302404), chicken F8 (422199), dog F8 (403875), domestic cat F8 (101092751), cow F8 (100271720) ...More
UniProtKB ID:
P00451, Q14286, Q5HY69
Gene ID:
  • Human(2157) Summary: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]
  • Mouse(14069) coagulation factor VIII
  • Rat(302470) coagulation factor VIII, procoagulant component
  • naked mole-rat(101725450) coagulation factor VIII, procoagulant component
  • domestic guinea pig(100720831) coagulation factor VIII, procoagulant component
  • Zebrafish(100302404) coagulation factor VIII, procoagulant component
  • chicken(422199) coagulation factor VIII, procoagulant component
  • dog(403875) coagulation factor VIII, procoagulant component
  • domestic cat(101092751) coagulation factor VIII, procoagulant component
  • cow(100271720) coagulation factor VIII, procoagulant component
  • sheep(100359363) coagulation factor VIII, procoagulant component
  • Domestic Rabbit(100303761) coagulation factor VIII, procoagulant component

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Antibodies

Product Number
Description
Species Reactivity
Application
SAB4500827
Anti-Factor VIII antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse
Application
ELISA
western blot
SAB1410356
Anti-F8 antibody produced in rabbit, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
SAB5300300
Monoclonal Anti-F8 antibody produced in mouse, clone 5E9B2, ascites fluid,
Species Reactivity
human
Application
ELISA
western blot
MAB038
Anti-Factor VIII Antibody, 83 kDa light chain, ascites fluid, Chemicon®,
Species Reactivity
human
Application
ELISA
western blot
05-861
Anti-vWF (von Willebrand Factor) Antibody, clone GMA-022, clone GMA-022, Upstate®, from mouse,
Species Reactivity
human
Application
western blot

esiRNA

Product Number
Description
Species
EHU158241
MISSION® esiRNA, targeting human F8,
Species
human