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EIF2AK3

eukaryotic translation initiation factor 2-alpha kinase 3

Synonyms:
PEK, PERK, WRS
Species:
Human EIF2AK3 (9451), Mouse Eif2ak3 (13666), Rat Eif2ak3 (29702), Horse EIF2AK3 (100066488), domestic cat EIF2AK3 (101095973), cow EIF2AK3 (535820), Zebrafish eif2ak3 (559564), dog EIF2AK3 (475756), chicken EIF2AK3 (422930), sheep EIF2AK3 (101110042) ...More
UniProtKB ID:
Q9NZJ5, A0AVH1, A0AVH2, B2RCU9, O95846, Q53QY0, Q53SB1
Gene ID:
  • Human(9451) Summary: The protein encoded by this gene phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation, and thus to a rapid reduction of translational initiation and repression of global protein synthesis. It is a type I membrane protein located in the endoplasmic reticulum (ER), where it is induced by ER stress caused by malfolded proteins. Mutations in this gene are associated with Wolcott-Rallison syndrome. [provided by RefSeq, Jan 2010]
  • Mouse(13666) eukaryotic translation initiation factor 2 alpha kinase 3
  • Rat(29702) eukaryotic translation initiation factor 2 alpha kinase 3
  • Horse(100066488) eukaryotic translation initiation factor 2-alpha kinase 3
  • domestic cat(101095973) eukaryotic translation initiation factor 2-alpha kinase 3
  • cow(535820) eukaryotic translation initiation factor 2-alpha kinase 3
  • Zebrafish(559564) eukaryotic translation initiation factor 2-alpha kinase 3
  • dog(475756) eukaryotic translation initiation factor 2-alpha kinase 3
  • chicken(422930) eukaryotic translation initiation factor 2-alpha kinase 3
  • sheep(101110042) eukaryotic translation initiation factor 2-alpha kinase 3
  • domestic guinea pig(100725836) eukaryotic translation initiation factor 2-alpha kinase 3
  • naked mole-rat(101713561) eukaryotic translation initiation factor 2-alpha kinase 3

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Antibodies

Product Number
Description
Species Reactivity
Application
HPA015737
Anti-EIF2AK3 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
SAB5700521
Anti-Phospho-PERK-T982 antibody produced in rabbit, ,
Species Reactivity
human, mouse, rat
Application
western blot
SAB4503650
Anti-E2AK3 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
ELISA
immunofluorescence
western blot
MABN842
Anti-PERK Antibody, clone 4F6.1, clone 4F6.1, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
SAB4301310
Anti-phospho-PEK/PERK (pThr981) antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human
Application
immunohistochemistry

Cell Lines

Product Number
Description
Species
MTOX1024
HepaRG™ Cells PERK (-/-), one vial,
Species
human

Proteins

Product Number
Description
Species
SRP5024
EIF2AK3 (563-1115), active, GST tagged human, PRECISIO® Kinase, recombinant, expressed in E. coli, ≥70% (SDS-PAGE), buffered aqueous glycerol solution,
Species
human
14-916-M
PEK, active, ,
Species
human

esiRNA

Product Number
Description
Species
EHU030881
MISSION® esiRNA, targeting human EIF2AK3, AC104134.2,
Species
human
EMU014751
MISSION® esiRNA, targeting mouse Eif2ak3,
Species
mouse