DFFA
DNA fragmentation factor, 45kDa, alpha polypeptide
Synonyms:
DFF-45, DFF1, ICAD
Species:
Human DFFA (1676), Mouse Dffa (13347), Rat Dffa (114214), naked mole-rat Dffa (101700734), domestic guinea pig Dffa (100719233), sheep DFFA (101114715), cow DFFA (507981), domestic cat DFFA (101096745), chicken DFFA (419451), Zebrafish dffa (436904)
UniProtKB ID:
Gene ID:
- Human(1676) Summary: Apoptosis is a cell death process that removes toxic and/or useless cells during mammalian development. The apoptotic process is accompanied by shrinkage and fragmentation of the cells and nuclei and degradation of the chromosomal DNA into nucleosomal units. DNA fragmentation factor (DFF) is a heterodimeric protein of 40-kD (DFFB) and 45-kD (DFFA) subunits. DFFA is the substrate for caspase-3 and triggers DNA fragmentation during apoptosis. DFF becomes activated when DFFA is cleaved by caspase-3. The cleaved fragments of DFFA dissociate from DFFB, the active component of DFF. DFFB has been found to trigger both DNA fragmentation and chromatin condensation during apoptosis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(13347) DNA fragmentation factor, alpha subunit
- Rat(114214) DNA fragmentation factor, alpha subunit
- naked mole-rat(101700734) DNA fragmentation factor, 45kDa, alpha polypeptide
- domestic guinea pig(100719233) DNA fragmentation factor, 45kDa, alpha polypeptide
- sheep(101114715) DNA fragmentation factor, 45kDa, alpha polypeptide
- cow(507981) DNA fragmentation factor, 45kDa, alpha polypeptide
- domestic cat(101096745) DNA fragmentation factor, 45kDa, alpha polypeptide
- chicken(419451) DNA fragmentation factor, 45kDa, alpha polypeptide
- Zebrafish(436904) DNA fragmentation factor, alpha polypeptide
- dog(487449) DNA fragmentation factor, 45kDa, alpha polypeptide
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-ICAD antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-ICAD antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution,
Species Reactivity
mouse
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Monoclonal Anti-DFFA, (C-terminal) antibody produced in mouse, clone 3A11, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
proximity ligation assay
western blot
proximity ligation assay
western blot
Anti-DFF45 antibody produced in rabbit, purified antibody (DEAE),
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-DFF45/35 Antibody, NT, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunoprecipitation (IP)
western blot
western blot