Skip to Content
MilliporeSigma

CYP11B2

cytochrome P450, family 11, subfamily B, polypeptide 2

Synonyms:
ALDOS, CPN2, CYP11B, CYP11BL, CYPXIB2, P-450C18, P450C18, P450aldo
Species:
Human CYP11B2 (1585), Mouse Cyp11b2 (13072), Rat Cyp11b2 (24294), domestic guinea pig Cyp11b2 (100379213), Domestic Rabbit CYP11B2 (100328543), cow CYP11B2 (282423), dog CYP11B2 (482071)
UniProtKB ID:
P19099, B0ZBE4, Q16726
Gene ID:
  • Human(1585) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the mitochondrial inner membrane. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency. [provided by RefSeq, Jul 2008]
  • Mouse(13072) cytochrome P450, family 11, subfamily b, polypeptide 2
  • Rat(24294) cytochrome P450, family 11, subfamily b, polypeptide 2
  • domestic guinea pig(100379213) aldosterone synthase
  • Domestic Rabbit(100328543) cytochrome P450, family 11, subfamily B, polypeptide 2
  • cow(282423) cytochrome P450, subfamily XIB (steroid 11-beta-hydroxylase), polypeptide 2
  • dog(482071) cytochrome P450, family 11, subfamily B, polypeptide 2

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Antibodies

Product Number
Description
Species Reactivity
Application
HPA049171
Anti-CYP11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
MABS1251
Anti-CYP11B2 Antibody, clone 41-17B, clone 41-17B, from mouse,
Species Reactivity
human, mouse
Application
immunofluorescence
immunohistochemistry
western blot
HPA057752
Anti-CYP11B2 antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry
HPA049565
Anti-Cyp11B2 Antibody Produced In Rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
MAB6021
Anti-Cytochrome P450 Aldosterone Synthase Antibody, clone 1G5, culture supernatant, clone 1G5, Chemicon®,
Species Reactivity
mouse, rat
Application
ELISA
immunocytochemistry
immunohistochemistry
western blot

Small Molecule - Inhibitor

Product Number
Description
Species
UC280
Ketoconazole, ,
Species
mouse, human, rat
K1003
Ketoconazole, 99.0-101.0% (EP, titration),
Species
mouse, human, rat

esiRNA

Product Number
Description
Species
EHU152861
MISSION® esiRNA, targeting human CYP11B2,
Species
human