CTSF
cathepsin F
Synonyms:
CATSF, CLN13
Species:
Human CTSF (8722), Mouse Ctsf (56464), Rat Ctsf (361704), domestic guinea pig Ctsf (100730626), naked mole-rat Ctsf (101719972), Horse CTSF (100058569), domestic cat CTSF (101099835), sheep CTSF (780471), Zebrafish ctsf (565588), dog CTSF (476010)
UniProtKB ID:
Gene ID:
- Human(8722) Summary: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. [provided by RefSeq, Jul 2008]
- Mouse(56464) cathepsin F
- Rat(361704) cathepsin F
- domestic guinea pig(100730626) cathepsin F
- naked mole-rat(101719972) cathepsin F
- Horse(100058569) cathepsin F
- domestic cat(101099835) cathepsin F
- sheep(780471) cathepsin F
- Zebrafish(565588) cathepsin F
- dog(476010) cathepsin F
- cow(509715) cathepsin F
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-CTSF antibody produced in mouse, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
western blot
Proteins
Product Number
Description
Species
Cathepsin F Active human, recombinant, expressed in FreeStyle™ 293-F cells, ≥90% (SDS-PAGE),
Species
human