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CTIF

CBP80/20-dependent translation initiation factor

Synonyms:
Gm672, KIAA0427
Species:
UniProtKB ID:
Gene ID:
  • Human(9811) Summary: CTIF is a component of the CBP80 (NCBP1; MIM 600469)/CBP20 (NCBP2; MIM 605133) translation initiation complex that binds cotranscriptionally to the cap end of nascent mRNA. The CBP80/CBP20 complex is involved in a simultaneous editing and translation step that recognizes premature termination codons (PTCs) in mRNAs and directs PTC-containing mRNAs toward nonsense-mediated decay (NMD). On mRNAs without PTCs, the CBP80/CBP20 complex is replaced with cytoplasmic mRNA cap-binding proteins, including EIF4G (MIM 600495), and steady-state translation of the mRNAs resumes in the cytoplasm (Kim et al., 2009 [PubMed 19648179]
  • Mouse(269037) CBP80/20-dependent translation initiation factor
  • Rat(364900) CBP80/20-dependent translation initiation factor
  • Zebrafish(100537309) CBP80/20-dependent translation initiation factor
  • chicken(770140) CBP80/20-dependent translation initiation factor
  • domestic cat(101087878) CBP80/20-dependent translation initiation factor
  • dog(490571) CBP80/20-dependent translation initiation factor
  • naked mole-rat(101716758) CBP80/20-dependent translation initiation factor
  • cow(615119) CBP80/20-dependent translation initiation factor
  • sheep(101114917) CBP80/20-dependent translation initiation factor
  • domestic guinea pig(100726220) CBP80/20-dependent translation initiation factor
  • Horse(100053562) CBP80/20-dependent translation initiation factor

Custom & Knockdown Gene Products

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  • Custom Gene Products

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esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human CTIF,
Species
human