CALR
calreticulin
Synonyms:
CRT, RO, SSA, cC1qR
Species:
Human CALR (811), Mouse Calr (12317), Rat Calr (64202), Domestic Rabbit CALR (100009050), Zebrafish calr (100332662), domestic cat CALR (101087384), domestic guinea pig Calr (100713922), cow CALR (281036), dog CALR (476694), naked mole-rat Calr (101719263) ...More
UniProtKB ID:
Gene ID:
- Human(811) Summary: Calreticulin is a multifunctional protein that acts as a major Ca(2+)-binding (storage) protein in the lumen of the endoplasmic reticulum. It is also found in the nucleus, suggesting that it may have a role in transcription regulation. Calreticulin binds to the synthetic peptide KLGFFKR, which is almost identical to an amino acid sequence in the DNA-binding domain of the superfamily of nuclear receptors. Calreticulin binds to antibodies in certain sera of systemic lupus and Sjogren patients which contain anti-Ro/SSA antibodies, it is highly conserved among species, and it is located in the endoplasmic and sarcoplasmic reticulum where it may bind calcium. The amino terminus of calreticulin interacts with the DNA-binding domain of the glucocorticoid receptor and prevents the receptor from binding to its specific glucocorticoid response element. Calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element and can inhibit androgen receptor and retinoic acid receptor transcriptional activities in vivo, as well as retinoic acid-induced neuronal differentiation. Thus, calreticulin can act as an important modulator of the regulation of gene transcription by nuclear hormone receptors. Systemic lupus erythematosus is associated with increased autoantibody titers against calreticulin but calreticulin is not a Ro/SS-A antigen. Earlier papers referred to calreticulin as an Ro/SS-A antigen but this was later disproven. Increased autoantibody titer against human calreticulin is found in infants with complete congenital heart block of both the IgG and IgM classes. [provided by RefSeq, Jul 2008]
- Mouse(12317) calreticulin
- Rat(64202) calreticulin
- Domestic Rabbit(100009050) calreticulin
- Zebrafish(100332662) calreticulin
- domestic cat(101087384) calreticulin
- domestic guinea pig(100713922) calreticulin
- cow(281036) calreticulin
- dog(476694) calreticulin
- naked mole-rat(101719263) calreticulin
- Zebrafish(30248) calreticulin
- sheep(101104396) calreticulin
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Calreticulin antibody produced in mouse, clone TO-11, tissue culture supernatant, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
Anti-Calreticulin Antibody, clone 1F16 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
horse, human, monkey, mouse, rat
Application
affinity binding assay
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-Calreticulin Antibody, arginylated (Nt-Glu18), from rabbit, purified by affinity chromatography,
Species Reactivity
human
Application
ELISA
immunocytochemistry
western blot
immunocytochemistry
western blot
Anti-Calreticulin Antibody, Upstate®, from rabbit,
Species Reactivity
xenopus, bovine, human, mouse, pig, rat
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-CALR antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
human, mouse, rat
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot