AUH
AU RNA binding protein/enoyl-CoA hydratase
Synonyms:
Species:
Human AUH (549), Mouse Auh (11992), Rat Auh (361215), chicken AUH (427269), Zebrafish auh (445182), sheep AUH (101109520), cow AUH (614716), domestic cat AUH (101096361), dog AUH (476348), naked mole-rat Auh (101719138)
UniProtKB ID:
Gene ID:
- Human(549) Summary: The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40-kDa precursor protein which is subsequently processed to a 32-kDa mature form. [provided by RefSeq, May 2010]
- Mouse(11992) AU RNA binding protein/enoyl-coenzyme A hydratase
- Rat(361215) AU RNA binding protein/enoyl-CoA hydratase
- chicken(427269) AU RNA binding protein/enoyl-CoA hydratase
- Zebrafish(445182) AU RNA binding protein/enoyl-Coenzyme A hydratase
- sheep(101109520) AU RNA binding protein/enoyl-CoA hydratase
- cow(614716) AU RNA binding protein/enoyl-CoA hydratase
- domestic cat(101096361) AU RNA binding protein/enoyl-CoA hydratase
- dog(476348) AU RNA binding protein/enoyl-CoA hydratase
- naked mole-rat(101719138) AU RNA binding protein/enoyl-CoA hydratase
- domestic guinea pig(100716715) AU RNA binding protein/enoyl-CoA hydratase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-AUH antibody produced in mouse, clone 2G12, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
western blot
western blot
Anti-AUH antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunohistochemistry