ATP6V1A
ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
Synonyms:
ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1
Species:
Human ATP6V1A (523), Mouse Atp6v1a (11964), Rat Atp6v1a (685232), Domestic Rabbit ATP6V1A (100347673), naked mole-rat Atp6v1a (101717344), chicken ATP6V1A (395821), dog ATP6V1A (487981), cow ATP6V1A (282147), domestic cat ATP6V1A (101091723), sheep ATP6V1A (101102025)
UniProtKB ID:
Gene ID:
- Human(523) Summary: This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [provided by RefSeq, Jul 2008]
- Mouse(11964) ATPase, H+ transporting, lysosomal V1 subunit A
- Rat(685232) ATPase, H+ transporting, lysosomal V1 subunit A
- Domestic Rabbit(100347673) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
- naked mole-rat(101717344) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
- chicken(395821) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
- dog(487981) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
- cow(282147) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
- domestic cat(101091723) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
- sheep(101102025) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
- domestic guinea pig(100733879) ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
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Antibodies
Product Number
Description
Species Reactivity
Application
Monoclonal Anti-ATP6V1A, (C-terminal) antibody produced in mouse, clone 4F5, purified immunoglobulin, buffered aqueous solution,
Species Reactivity
human
Application
ELISA
immunofluorescence
immunohistochemistry
western blot
immunofluorescence
immunohistochemistry
western blot
Anti-ATP6V1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot
Anti-ATP6V1A antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
western blot
western blot