AIFM1
apoptosis-inducing factor, mitochondrion-associated, 1
Synonyms:
AIF, CMTX4, COWCK, COXPD6, PDCD8
Species:
Human AIFM1 (9131), Mouse Aifm1 (26926), Rat Aifm1 (83533), Horse AIFM1 (100054546), cow AIFM1 (535714), sheep AIFM1 (100188912), sheep AIFM1 (101121574), Zebrafish aifm1 (373125), chicken AIFM1 (428688), domestic cat AIFM1 (768258) ...More
UniProtKB ID:
Gene ID:
- Human(9131) Summary: This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6, which results in a severe mitochondrial encephalomyopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10. [provided by RefSeq, May 2010]
- Mouse(26926) apoptosis-inducing factor, mitochondrion-associated 1
- Rat(83533) apoptosis-inducing factor, mitochondrion-associated 1
- Horse(100054546) apoptosis-inducing factor, mitochondrion-associated, 1
- cow(535714) apoptosis-inducing factor, mitochondrion-associated, 1
- sheep(100188912) apoptosis-inducing factor, mitochondrion-associated, 1
- sheep(101121574) apoptosis-inducing factor, mitochondrion-associated, 1
- Zebrafish(373125) apoptosis-inducing factor, mitochondrion-associated 1
- chicken(428688) apoptosis-inducing factor, mitochondrion-associated, 1
- domestic cat(768258) apoptosis-inducing factor, mitochondrion-associated, 1
- domestic guinea pig(100730787) apoptosis-inducing factor, mitochondrion-associated, 1
- naked mole-rat(101698690) apoptosis-inducing factor, mitochondrion-associated, 1
- Domestic Rabbit(100347778) apoptosis-inducing factor, mitochondrion-associated, 1
- dog(481048) apoptosis-inducing factor, mitochondrion-associated, 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-AIFM1 antibody produced in rabbit, affinity isolated antibody,
Species Reactivity
bovine, dog, horse, human, mouse, pig, rabbit, rat
Application
western blot
Anti-AIF Antibody, clone 3C11, clone 3C11, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-AIF Antibody, internal domain, Chemicon®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-AIF Antibody, clone 1E4 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry
immunohistochemistry
western blot
immunocytochemistry
immunohistochemistry
western blot
Anti-AIF (Apoptosis Inducing Factor) Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
western blot