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B1901

Sigma-Aldrich

Bradykinin Fragment 2-9

≥97% (HPLC)

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About This Item

Empirical Formula (Hill Notation):
C44H61N11O10
CAS Number:
16875-11-9
Molecular Weight:
904.02
MDL number:
MFCD00076264
UNSPSC Code:
12352200
PubChem Substance ID:
24891619
NACRES:
NA.32

Quality Level

200

Assay

≥97% (HPLC)

form

powder

UniProt accession no.

P01042

storage temp.

−20°C

SMILES string

NC(=N)NCCCC(NC(=O)C(Cc1ccccc1)NC(=O)C2CCCN2C(=O)C(CO)NC(=O)C(Cc3ccccc3)NC(=O)CNC(=O)C4CCCN4C(=O)C5CCCN5)C(O)=O

InChI

1S/C44H61N11O10/c45-44(46)48-20-8-16-30(43(64)65)51-38(59)32(24-28-13-5-2-6-14-28)52-40(61)35-18-10-22-55(35)42(63)33(26-56)53-37(58)31(23-27-11-3-1-4-12-27)50-36(57)25-49-39(60)34-17-9-21-54(34)41(62)29-15-7-19-47-29/h1-6,11-14,29-35,47,56H,7-10,15-26H2,(H,49,60)(H,50,57)(H,51,59)(H,52,61)(H,53,58)(H,64,65)(H4,45,46,48)

InChI key

ZZHVXIPXTCBVBE-UHFFFAOYSA-N

Gene Information

human ... KNG1 (includes EG:3827)

Amino Acid Sequence

Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg

Biochem/physiol Actions

Inhibits ACE (angiotensin converting enzyme) and potentiates bradykinin (BK).
The des-arginine-1 bradykinin (BK) peptide (2-9) has no detectable contractile activity, inhibits ACE (angiotensin converting enzyme) and potentiates BK.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000408983
0000408983
0000395890
0000387217
0000387217

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N P Ewing et al.
Journal of mass spectrometry : JMS, 36(8), 875-881 (2001-08-28)
Apparent gas-phase basicities (GB(app)s) for [M + H]+ of bradykinin, des-Arg1-bradykinin and des-Arg9-bradykinin have been assigned by deprotonation reactions of [M + 2H]2+ in a Fourier transform ion cyclotron resonance mass spectrometer. With a GB(app) of 225.8 +/- 4.2 kcal
Julia Laskin et al.
Journal of the American Chemical Society, 125(6), 1625-1632 (2003-02-06)
Time- and collision energy-resolved surface-induced dissociation (SID) of des-Arg(1)- and des-Arg(9)-bradykinin on a fluorinated self-assembled monolayer (SAM) surface was studied by use of a novel Fourier transform ion cyclotron resonance mass spectrometer (FT-ICR MS) specially equipped to perform SID experiments.
S Mohammed et al.
Journal of mass spectrometry : JMS, 36(12), 1260-1268 (2001-12-26)
A novel tandem quadrupole mass spectrometer is described that enables gaseous collision-induced dissociation (CID) and surface-induced dissociation (SID) experiments. The instrument consists of a commercially available triple quadrupole mass spectrometer connected to an SID region and an additional, orthogonal quadrupole
G S Bedi et al.
Biochimica et biophysica acta, 842(1), 90-99 (1985-09-27)
Four hybridoma cell lines have been established that secrete monoclonal antibodies to nonapeptide bradykinin. Bradykinin coupled to ovalbumin, using 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide as coupling agent, was used to immunize BALB/c mice. Spleen cells from the immunized animals were fused to P3-X63-AG8-653 mouse
Cristiano R Jesse et al.
Pharmacology, biochemistry, and behavior, 91(4), 573-580 (2008-10-22)
The objective of this study was to extend our previous findings by investigating in greater detail the mechanisms that might be involved in the antinociceptive action of p-methoxyl-diphenyl diselenide, (MeOPhSe)(2), in mice. The pretreatment with nitric oxide precursor, l-arginine (600
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