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A7910

Sigma-Aldrich

Apolipoprotein C-II from human plasma

≥95% (SDS-PAGE)

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About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.77

biological source

human

Quality Level

Assay

≥95% (SDS-PAGE)

form

powder

mol wt

average mol wt 8.8 kDa

technique(s)

ligand binding assay: suitable

UniProt accession no.

storage temp.

−20°C

Gene Information

human ... APOC2(344)

General description

Apolipoprotein C-II (APOC2/apoC-II), a small exchangeable apolipoprotein, is expressed in the liver and secreted into plasma. It is present on the triglyceride-rich lipoproteins (TRL), like chylomicrons (CM) and very-low-density lipoproteins (VLDL), and high-density lipoproteins (HDL), mainly during fasting. The intestine, macrophages, adipose tissue, brain, skin, lungs, retina, and retinal pigment epithelium are among the tissues that produce ApoC-II.

Application

Apolipoprotein C-II activates lipoprotein lipase and has been used in a study to assess HDL proteome in hemodialysis patients. An excess of apolipoprotein C-II is associated with increased triglyceride-rich particles and alterations in HDL particle distribution.

Biochem/physiol Actions

Apolipoprotein C2 (APOC2) serves as an activator of lipoprotein lipase. It is involved in the hydrolysis of triglycerides (TG) on TG-rich lipoproteins (TRL) to release free fatty acids (FA). Higher expression of APOC2 is observed in patient-derived glioblastoma stem cells, hypopharyngeal cancer, invasive ductal breast cancer, clear cell renal cell carcinoma, gastric cancer, centroblastic lymphoma, early-stage colorectal tumor, and skin squamous cell carcinoma. ApoC-2 is considered as a new sensitive biomarker for diagnosing Takayasu arteritis (TAK).
Activates lipoprotein lipase

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Deregulation of apolipoprotein C2 gene in cancer: A potential metabolic vulnerability.
Yuqiao Liu et al.
Clinical and translational medicine, 11(6), e406-e406 (2021-06-30)
Anna Wolska et al.
Atherosclerosis, 267, 49-60 (2017-11-04)
Apolipoprotein C-II (apoC-II) is a small exchangeable apolipoprotein found on triglyceride-rich lipoproteins (TRL), such as chylomicrons (CM) and very low-density lipoproteins (VLDL), and on high-density lipoproteins (HDL), particularly during fasting. ApoC-II plays a critical role in TRL metabolism by acting
Alain Mangé et al.
PloS one, 7(3), e34107-e34107 (2012-04-04)
Aside from a decrease in the high-density lipoprotein (HDL) cholesterol levels, qualitative abnormalities of HDL can contribute to an increase in cardiovascular (CV) risk in end-stage renal disease (ESRD) patients undergoing chronic hemodialysis (HD). Dysfunctional HDL leads to an alteration
Natsuko Tamura et al.
Scientific reports, 11(1), 18958-18958 (2021-09-25)
Takayasu arteritis (TAK) is an autoimmune systemic arteritis of unknown etiology. Although a number of investigators have attempted to determine biomarkers for diagnosing TAK, there exist no specific serological markers of this intractable disease. We undertook the exploration of novel
Anastazia A Kei et al.
Metabolism: clinical and experimental, 61(7), 906-921 (2012-02-07)
The focus of this review is on the role of apolipoprotein C-II (apoC-II) in lipoprotein metabolism and the potential effects on the risk of cardiovascular disease (CVD). We searched PubMed/Scopus for articles regarding apoC-II and its role in lipoprotein metabolism

Articles

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

Lipoproteins package cholesterol for transport in plasma, essential for lipid transport and cellular function in the body.

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