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82934

Sigma-Aldrich

7-Hydroxycitronellal

Odorant used in allergy studies

Synonym(s):

7-Hydroxy-3,7-dimethyloctanal, Citronellal hydrate

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About This Item

Empirical Formula (Hill Notation):
C10H20O2
CAS Number:
107-75-5
Molecular Weight:
172.26
EC Number:
203-518-7
MDL number:
MFCD00014681
UNSPSC Code:
12352200
PubChem Substance ID:
57652938
NACRES:
NA.52

grade

for molecular biology

Quality Level

100

Assay

≥95.0% (GC)

form

powder

density

0.92 g/mL at 20 °C (lit.)

storage temp.

room temp

SMILES string

[H]C(CC(C)CCCC(O)(C)C)=O

InChI

1S/C10H20O2/c1-9(6-8-11)5-4-7-10(2,3)12/h8-9,12H,4-7H2,1-3H3

InChI key

WPFVBOQKRVRMJB-UHFFFAOYSA-N

General description

7-Hydroxycitronellal is fragrant sensitizer added frequently to deodorants and perfumes. It is one of the allergens responsible for axillary dermatitis.

Application

Suitable for
  • contact sensitization studies to identify allergens present in cosmetic preparations
  • elucidation of molecular pathways related to allergic reactions
  • analytical standard

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Nadège Ade et al.
Toxicological sciences : an official journal of the Society of Toxicology, 107(2), 451-460 (2008-11-27)
Electrophilicity is one of the most common features of skin contact sensitizers and is necessary for protein haptenation. The Keap1 (Kelch-like ECH-associated protein 1)/Nrf2 -signaling pathway is dedicated to the detection of electrophilic stress in cells leading to the upregulation
B Kreilgård et al.
Journal of the American Academy of Dermatology, 21(4 Pt 2), 836-838 (1989-10-01)
The choice of vehicle for patch test materials is important for the bioavailability and stability of the allergens. Examples are given from the standardization of the TRUE Test and include caine mix, Kathon CG, and fragrance mix.
M Cluzel-Tailhardat et al.
Toxicology letters, 174(1-3), 98-109 (2007-10-16)
A critical step in the induction of allergic contact dermatitis is the interaction of haptens with immature dendritic cells (iDC) leading to their activation. Therefore iDC appear as suitable targets for the evaluation of the sensitizing properties of haptens with
S Heydorn et al.
Contact dermatitis, 48(6), 324-330 (2003-10-09)
Recently, we showed that 10 x 2% of consecutively patch-tested hand eczema patients had a positive patch test to a selection of fragrances containing fragrances relevant to hand exposure. In this study, we used repeated skin exposure to a patch
Susan P Felter et al.
Regulatory toxicology and pharmacology : RTP, 37(1), 1-10 (2003-03-29)
The National Academy of Science (NAS) risk assessment paradigm has been widely accepted as a framework for estimating risk from exposure to environmental chemicals (NAS, 1983). Within this framework, quantitative risk assessments (QRAs) serve as the cornerstone of health-based exposure
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