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PVP40

Sigma-Aldrich

Polyvinylpyrrolidone

average mol wt 40,000

Synonym(s):

PVP, Polyvidone, Povidone

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About This Item

Linear Formula:
(C6H9NO)n
CAS Number:
9003-39-8
MDL number:
MFCD00149016
UNSPSC Code:
12161700
PubChem Substance ID:
24899319
NACRES:
NA.25
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biological source

synthetic (oragnic)

Quality Level

200

form

powder

mol wt

average mol wt 40,000

impurities

<5.0% water (Karl Fischer)

viscosity number

29-32(lit.)

solubility

water: 100 mg/mL, clear, colorless to light yellow

application(s)

agriculture

SMILES string

C=CN1CCCC1=O

InChI

1S/C6H9NO/c1-2-7-5-3-4-6(7)8/h2H,1,3-5H2

InChI key

WHNWPMSKXPGLAX-UHFFFAOYSA-N

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General description

Polyvinylpyrrolidone (PVP) can form complexes with phenolics and alkaloids. The complex formation allows removal of phenolics and alkaloids from plant samples, thereby inhibiting any modification of proteins by them and any hindrance they may cause in spectrophotometric determinations of protein content. PVP might also enhances the stability of enzymes.[1]
Polyvinylpyrrolidone (PVP), a multifunctional synthetic polymer, finds utility in life science and biochemical research. This water-soluble polymer is versatile, serving as a stabilizing agent, emulsifier, suspending agent, solubilizing agent, protective colloid, and complexing agent. Its protective colloid properties are particularly valuable in stabilizing proteins, enzymes, and other biological substances.

Application

Polyvinylpyrrolidone has been used in the purification of glutamine synthetases from plant samples.[2] It has been used to block the PVDF (polyvinylidene difluoride) membrane and to avoid nonspecific binding.[3][4]

Features and Benefits

  • Highly versatile surfactant for your life science and biochemical research
  • Excellent Solubilizing agent and Complexing agent

Other Notes

Polyvinylpyrrolidone is a component of Denhardt′s Solution and is included at a concentration of 1% (w/v) in the standard 50X stock solution.
For additional information on our range of Biochemicals, please complete this form.

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
WXBF5204V
0000423892
0000423892
0000367727
0000412018

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Glutamine Synthetases of Higher Plants : Evidence for a Specific Isoform Content Related to Their Possible Physiological Role and Their Compartmentation within the Leaf.
McNally SF et al.
Plant Physiology, 72, 22-22 (1983)
Structural analysis of N- and O-glycans released from glycoproteins.
Jensen PH et al.
Nature Protocols, 7, 1299-1299 (2012)
Manna Crespan et al.
Scientific reports, 10(1), 7206-7206 (2020-05-01)
'Glera' and 'Ribolla Gialla' are the most economically relevant local grapevine cultivars of Friuli Venezia Giulia region (north-eastern Italy). 'Glera' is used to produce the world-renowned Prosecco wine. 'Ribolla Gialla' cultivation is constantly increasing due to the strong demand for
Quantification of the Antioxidant Activity in Salt-Stressed Tissues.
Maksimovic JJD and Zivanovic BD
Plant Salt Tolerance: Methods and Protocols, 237-237 (2012)
Angiotensin II inhibits insulin signaling in aortic smooth muscle cells at multiple levels. A potential role for serine phosphorylation in insulin/angiotensin II crosstalk.
Folli F et al.
The Journal of Clinical Investigation, 100, 2158-2158 (1997)
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Protocols

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Learn Northern and Southern blotting basics, with protocols and applications for macromolecule transfer to membrane supports.

Northern & Southern Blot Protocols

Learn Northern and Southern blotting basics, with protocols and applications for macromolecule transfer to membrane supports.

Northern & Southern Blot Protocols

Learn Northern and Southern blotting basics, with protocols and applications for macromolecule transfer to membrane supports.

Northern & Southern Blot Protocols

Learn Northern and Southern blotting basics, with protocols and applications for macromolecule transfer to membrane supports.

Questions

1–3 of 3 Questions  

  1. I'm interested in using this product for reducing the inhibitory effects of polyphenols during ELISA extraction of walnuts. Do you think this product would help this?

    1 answer

    1. This product has not been tested for reducing inhibitory effects of polyphenols during ELISA extraction of walnuts. However, literature suggests that polyvinylpyrrolidone (PVP) may be effective, although the molecular weight used is not specified. The reference is: Abiodun A. Ogunjimi, Prabhakara V. Choudary, "Adsorption of endogenous polyphenols relieves the inhibition by fruit juices and fresh produce of immuno-PCR detection of Escherichia coli 0157:H7," FEMS Immunology & Medical Microbiology, Volume 23, Issue 3, March 1999, Pages 213–220.

      Contacting the article's author may provide information on the specific product number used in the experiment.

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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