Piperidine is a heterocyclic amine with a six-membered ring containing five methylene bridges (-CH2-) and one amine bridge (-NH-). Numerous alkaloids, pharmaceuticals, agrochemicals, and synthetic and biological intermediates contain the piperidine moiety. The commercial applications of piperidine include: solvent for curing agents and epoxy resins. In organic synthesis, it serves as an intermediate.
Application
Piperidine is used:
As an organic structure-directing agent in the synthesis of titanoborosilicate precursor.[1]
As stock solution with NMP (1-methyl-2-pyrrolidinone) to deprotect the Fmoc group in the preparation of N-methylated cyclic peptides.[2]
Features and Benefits
Piperidine is more basic than pyridine and also a good nucleophile.[3]
Analysis Note
Assay (GC, area%): ≥ 99.0 % (a/a) Density (d 20 °C/ 4 °C): 0.861 - 0.863 Water (K. F.): ≤ 0.50 % Identity (IR): passes test
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This protocol presents a detailed description of the synthesis of N-methylated cyclic peptides. N-methylation is a powerful technique to modulate the physicochemical properties of peptides by introducing one or more methyl groups into the peptidic amide bonds. Together with peptide
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