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LM1905

Avanti

17:0-20:4 PI(3,5)P2

Avanti Research™ - A Croda Brand LM1905, powder

Synonym(s):

1-heptadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phospho-(1′-myo-inositol-3′,5′-bisphosphate) (ammonium salt)

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About This Item

Empirical Formula (Hill Notation):
C46H92N3O19P3
CAS Number:
1246304-71-1
Molecular Weight:
1084.15
UNSPSC Code:
12352211
NACRES:
NA.25

form

powder

manufacturer/tradename

Avanti Research™ - A Croda Brand LM1905

packaging

1 ea of 1 × (with stopper and crimp cap (LM1905-1EA))

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(O[C@H]1[C@H](O)[C@@H](OP(O)([O-])=O)[C@H](O)[C@@H](OP([O-])(O)=O)[C@H]1O)=O)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)COC(CCCCCCCCCCCCCCCC)=O.[NH4+].[NH4+].[NH4+]

General description

Phosphorylated phosphatidylinositol (PIP) lipids are low-abundance lipids of which phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is rare. PI(3,5)P2 is localized to many cellular compartments.

Biochem/physiol Actions

Phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2) is a signaling molecule involved in various cellular pathways. It is significant for cellular homeostasis and adaptation. Insufficiency of PI(3,5)P2 is associated with nervous system disorders.

Packaging

2 mL Amber Serum Vial with Stopper and Crimp Cap (LM1905-1EA)

Legal Information

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Storage Class Code

11 - Combustible Solids

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Natsuko Jin et al.
Biochemical Society transactions, 44(1), 177-184 (2016-02-11)
Phosphorylated phosphatidylinositol lipids are crucial for most eukaryotes and have diverse cellular functions. The low-abundance signalling lipid phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2] is critical for cellular homoeostasis and adaptation to stimuli. A large complex of proteins that includes the lipid kinase Fab1-PIKfyve
Yvonne Lindsay et al.
Journal of cell science, 119(Pt 24), 5160-5168 (2006-12-13)
Phosphatidylinositol (3,4,5) trisphosphate [PtdIns(3,4,5)P3] is a lipid second messenger, produced by Type I phosphoinositide 3-kinases (PI 3-kinases), which mediates intracellular responses to many growth factors. Although PI 3-kinases are implicated in events at both the plasma membrane and intracellular sites
Yimei Huang et al.
Frontiers in microbiology, 10, 1016-1016 (2019-06-06)
Fungal glucosylceramide plays important role in cell division, hyphal formation and growth, spore germination and the modulation of virulence and has recently been considered as target for small molecule inhibitors. In this study, we characterized CgGCS, a protein encoding a
Amber J McCartney et al.
BioEssays : news and reviews in molecular, cellular and developmental biology, 36(1), 52-64 (2013-12-11)
Recent studies of the low abundant signaling lipid, phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2 ), reveal an intriguingly diverse list of downstream pathways, the intertwined relationship between PI(3,5)P2 and PI5P, as well as links to neurodegenerative diseases. Derived from the structural lipid phosphatidylinositol

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