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A9563

Sigma-Aldrich

4-Aminophenylmercuric acetate

≥90% (titration)

Synonym(s):

4-(Acetoxymercurio)aniline, APMA

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About This Item

Linear Formula:
CH3CO2HgC6H4NH2
CAS Number:
6283-24-5
Molecular Weight:
351.75
Beilstein:
3664749
EC Number:
228-497-1
MDL number:
MFCD00007820
UNSPSC Code:
12352103
PubChem Substance ID:
57653899
NACRES:
NA.22

Quality Level

100

Assay

≥90% (titration)

form

powder

mp

163-165 °C (lit.)

solubility

DMSO: soluble 10 mg/mL
H2O: soluble 5 mM
glacial acetic acid: soluble 50 mg/mL

SMILES string

CC(=O)O[Hg]c1ccc(N)cc1

InChI

1S/C6H6N.C2H4O2.Hg/c7-6-4-2-1-3-5-6;1-2(3)4;/h2-5H,7H2;1H3,(H,3,4);/q;;+1/p-1

InChI key

RXSUFCOOZSGWSW-UHFFFAOYSA-M

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Biochem/physiol Actions

An organomercurial activator of matrix metalloproteinases.

Signal Word

Danger

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - STOT RE 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
SLCK8336
SLCK8335
SLCK8334
SLCN7376
MKCL0389

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Jan-Olof Winberg et al.
European journal of biochemistry, 270(19), 3996-4007 (2003-09-27)
In the leukemic macrophage cell-line THP-1, a fraction of the secreted matrix metalloproteinase 9 (MMP-9) is linked to the core protein of chondroitin sulfate proteoglycans (CSPG). Unlike the monomeric and homodimeric forms of MMP-9, the addition of exogenous CaCl2 to
K R French et al.
Equine veterinary journal, 36(3), 261-266 (2004-05-19)
Acute laminitis is characterised by hoof lamellar dermal-epidermal separation at the basement membrane (BM) zone. Hoof lamellar explants cultured in vitro can also be made to separate at the basement membrane zone and investigating how this occurs may give insight
A Bianchi et al.
Osteoarthritis and cartilage, 24(11), 1961-1969 (2016-10-21)
Fibroblast Growth Factor 23 (FGF23) may represent an attractive candidate that could participate to the osteoarthritic (OA)-induced phenotype switch of chondrocytes. To address this hypothesis, we investigated the expression of FGF23, its receptors (FGFRs) and co-receptor (Klotho) in human cartilage
Tomas Friman et al.
PloS one, 7(3), e34082-e34082 (2012-04-06)
Stroma properties affect carcinoma physiology and direct malignant cell development. Here we present data showing that α(V)β(3) expressed by stromal cells is involved in the control of interstitial fluid pressure (IFP), extracellular volume (ECV) and collagen scaffold architecture in experimental
Fiia P Gäddnäs et al.
Critical care (London, England), 14(2), R49-R49 (2010-04-02)
Matrix metalloproteinases (MMPs) have various roles in inflammatory states. They seem to be able to modulate endothelial barriers and regulate the activity of chemokines and cytokines. The timely development of the levels during severe sepsis and thereafter have not been
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