531413

2,2-Difluoro-2-(fluorosulfonyl)acetic acid

97%

• Synonym(s): (Fluorosulfonyl)difluoroacetic acid
• Linear Formula: FSO₂CF₂CO₂H
• CAS Number: 1717-59-5
• Molecular Weight: 178.09
• MDL number: MFCD01320807
• UNSPSC Code: 12352100
• PubChem Substance ID: 24877815
• NACRES: NA.22

Properties

• Quality Level: 100
• Assay: 97%
• reaction suitability: reaction type: click chemistry
• refractive index: n20/D 1.36 (lit.)
• bp: 153 °C (lit.)
• density: 1.723 g/mL at 25 °C (lit.)
• SMILES string: OC(=O)C(F)(F)S(F)(=O)=O
• InChI: 1S/C2HF3O4S/c3-2(4,1(6)7)10(5,8)9/h(H,6,7)
• InChI key: VYDQUABHDFWIIX-UHFFFAOYSA-N

Description

General description

2,2-Difluoro-2-(fluorosulfonyl)acetic acid reagent is employed as a difluorocarbene source for difluoromethylation of phenolic hydroxyl groups.

Application

2,2-Difluoro-2-(fluorosulfonyl)acetic acid may be used in the following processes:

• Preparation of 1-difluoromethyl-2-oxo-1,2-dihydropyridine analogs by reacting with the corresponding 2-chloropyridines.
• Prepration of silyl fluorosulfonyldifluoroacetate as new highly efficient difluorocarbene reagent for cyclopropanation of alkenes.
• Regio- and stereoselective free radical fluoroalkylation of terminal alkenes and alkynes with iododifluoromethanesulfonamides.

Safety Information

• Pictograms: GHS06,GHS05
• Signal Word: Danger
• Hazard Statements: H300 + H310,H314
• Precautionary Statements: P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P361 + P364 - P405
• Hazard Classifications: Acute Tox. 2 Oral - Skin Corr. 1A
• Storage Class Code: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• WGK: WGK 3
• Flash Point(F): 230.0 °F - closed cup
• Flash Point(C): 110 °C - closed cup
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves