442631

Coumarin 6

98%

• Synonym(s): 3-(2-Benzothiazolyl)-7-(diethylamino)coumarin, 3-(2-Benzothiazolyl)-N,N-diethylumbelliferylamine
• Empirical Formula (Hill Notation): C₂₀H₁₈N₂O₂S
• CAS Number: 38215-36-0
• Molecular Weight: 350.43
• Beilstein: 1085798
• EC Number: 253-830-2
• MDL number: MFCD00041869
• UNSPSC Code: 12352103
• PubChem Substance ID: 24867935
• NACRES: NA.23

Properties

• Quality Level: 100
• Assay: 98%
• form: solid
• mp: 208-210 °C (lit.)
• λmax: 444 nm
• fluorescence: λ_em 505 nm in ethanol (Lasing peak 534 nm, lasing range 515 - 558 nm (DMSO), pump source XeCl (308 nm))
• OLED Device Performance: ITO/Alq₃:Coumarin 6/Mg:Ag;
  • Color: green
  • Max. EQE: 2.5 %
• SMILES string: CCN(CC)c1ccc2C=C(C(=O)Oc2c1)c3nc4ccccc4s3
• InChI: 1S/C20H18N2O2S/c1-3-22(4-2)14-10-9-13-11-15(20(23)24-17(13)12-14)19-21-16-7-5-6-8-18(16)25-19/h5-12H,3-4H2,1-2H3
• InChI key: VBVAVBCYMYWNOU-UHFFFAOYSA-N

Description

General description

Coumarin 6 (C6) is a derivative of coumarin with a benzothiazolyl group at the position 3. It emits fluorescence in solid and solution state[1] and is used as fluorescent dye to stain organelles.[2] C6 is majorly used as blue-green spectrum laser dye and is microenvironment sensitive.[3]

Coumarin 6 is a fluorescent dye that belongs to the 7-diethylaminocoumarin series that can be used in a variety of biological activities. It can be used as a dopant that exhibits green light (500 nm) in optoelectronic applications.[4][5][6]

Application

Coumarin 6 dye can be used in the labeling and visualization of polymeric nanoparticles in biological applications, such as oral drug delivery systems for cancer.[7] It can also be used in development of electroluminescent devices such as organic light emitting diodes (OLEDs).[8][9]

Coumarin 6 has been used as a hydrophobic fluorescent dye

• in block copolymer (BCP)-based micelle based drug delivery studies in glioma cell lines[10]
• in combination with flufenamic acid (FA) based nanoprodrug uptake in glioma cells[11]
• in poly(lactic-co-glycolic acid) (PLGA) based elvitegravir nanoprodrug uptake studies[12]

Laser dye

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves