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Key Documents

123463

Sigma-Aldrich

1,2-Cyclohexanedicarboxylic anhydride, predominantly cis

95%

Synonym(s):

Hexahydrophthalic anhydride

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About This Item

Empirical Formula (Hill Notation):
C8H10O3
CAS Number:
Molecular Weight:
154.16
EC Number:
MDL number:
UNSPSC Code:
12162002
PubChem Substance ID:
NACRES:
NA.23

Assay

95%

form

solid

bp

158 °C/17 mmHg (lit.)

mp

32-34 °C (lit.)

SMILES string

O=C1OC(=O)[C@H]2CCCC[C@@H]12

InChI

1S/C8H10O3/c9-7-5-3-1-2-4-6(5)8(10)11-7/h5-6H,1-4H2/t5-,6+

InChI key

MUTGBJKUEZFXGO-OLQVQODUSA-N

General description

Predominantly cis 1,2-cyclohexanedicarboxylic anhydride (HHPA) is a cyclic anhydride that can be used for a variety of applications such as: plasticizer, rust inhibitor, and a curing agent for epoxy based resins.

Application

HPPA, in combination with triethaylamine (TEA), can be used as a polymerization initiator in the preparation of polyester based resins. It can also be used as a hardener to cure 1,4-butanediol diglycidyl ether which can be used as an epoxy based system for electronic devices.

Pictograms

Health hazardCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Resp. Sens. 1 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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Gunvor A Johannesson et al.
Biomedical chromatography : BMC, 22(3), 327-332 (2007-10-17)
An immunoaffinity extraction (IAE) column was prepared for extraction of adducts between human serum albumin (HSA) and hexahydrophthalic anhydride (HHPA). HHPA is a strong sensitizer inducing immunoglobulin E antibodies in vivo. Polyclonal antibodies from a rabbit immunized with keyhole limpet
Gunvor Johannesson et al.
Toxicology and applied pharmacology, 194(1), 69-78 (2004-01-20)
Hexahydrophthalic anhydride (HHPA), an industrially important chemical, is a highly allergenic compound. The aim of this work was to identify proteins in nasal lavage fluid (NLF) that form adducts with HHPA. Such bindings may induce production of specific immunoglobulin E
S Rosqvist et al.
Scandinavian journal of work, environment & health, 27(2), 133-139 (2001-06-21)
The aim of this study was to evaluate the applicability of total plasma protein adducts (TPPA) of 2 sensitizing low-molecular-weight allergens, hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA), as biomarkers of long-term exposure. Urine samples from occupationally exposed workers were
K Jellema et al.
Clinical anatomy (New York, N.Y.), 20(5), 524-529 (2007-04-07)
Spinal dural arteriovenous fistulas (SDAVF) consist of a shunt between a radicular artery and a radicular vein, resulting in a progressive paraparesis. They are most prevalent in middle-aged men (male to female ratio 5 to 1). It is unknown why
Peter E Westerweel et al.
Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology, 14(6), 294-297 (2005-11-16)
Understanding neovascularization is an important prerequisite for therapeutic advances aimed at the salvation of ischemic tissues. We explored an alternative strategy to corrosion casting for visualizing neovascularization in a rat hindlimb ischemia model. Rats were subjected to hindlimb ischemia by

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