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M6876

Sigma-Aldrich

D-Mannose 6-phosphate disodium salt hydrate

≥97.0% dry basis (enzymatic)

Synonym(s):

Sodium (2R,3R,4S,5S)-2,3,4,5-tetrahydroxy-6-oxohexyl phosphate

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About This Item

Empirical Formula (Hill Notation):
C6H11Na2O9P · xH2O
CAS Number:
Molecular Weight:
304.10 (anhydrous basis)
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25

biological source

wood (birch wood)

Quality Level

Assay

≥97.0% dry basis (enzymatic)

form

powder

impurities

≤1.0% total fructose 6-phosphate and glucose 6-phosphate

color

white to off-white

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

cation traces

Na: 13.2-17.0% (dry basis)

storage temp.

−20°C

SMILES string

[Na+].[Na+].[H]O[H].OC1O[C@H](COP([O-])([O-])=O)[C@@H](O)[C@H](O)[C@@H]1O

InChI

1S/C6H13O9P.2Na.H2O/c7-3-2(1-14-16(11,12)13)15-6(10)5(9)4(3)8;;;/h2-10H,1H2,(H2,11,12,13);;;1H2/q;2*+1;/p-2/t2-,3-,4+,5+,6?;;;/m1.../s1

InChI key

UUWJZXLTPORJKW-XTAHGNKUSA-L

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General description

Mannose is a monosaccharide.

Application

Mannose has been used in a study to assess the phenotyping of primary human microglia. It has also been used in a study to investigate the identification of Anogeissus latifolia Wallich and analyze refined gum ghatti.

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Jeroen Melief et al.
Glia, 60(10), 1506-1517 (2012-06-29)
Much is still unknown about mechanisms underlying the phenotypical and functional versatility of human microglia. Therefore, we developed a rapid procedure to isolate pure microglia from postmortem human brain tissue and studied their immediate ex vivo phenotype and responses to
Eiji Sakai et al.
Journal of natural medicines, 67(2), 276-280 (2012-06-26)
Natural medicinal exudates such as gum arabic are high-molecular-weight natural polysaccharides and are highly soluble in water. The dissolved solutions of these exudates show viscous behavior and exhibit favorable emulsion stability. These exudates have been widely used not only as
Changsuo Xia et al.
Orthopedics, 35(7), e1056-e1060 (2012-07-13)
The purpose of this study was to investigate the preventive effect of mannose-6-phosphate on flexor tendon adhesion formation. From a total of 84 adult New Zealand White rabbits, 36 were randomly divided into 2 groups, the normal saline group and
G K Cury et al.
Gene, 524(1), 59-64 (2013-04-10)
Mucolipidosis II and III (MLII and MLIII) alpha/beta are rare autosomal recessive lysosomal storage diseases (LSDs) caused by pathogenic variations in the GNPTAB gene. GNPTAB gene codes for the α and β subunits of phosphotransferase, the enzyme responsible for synthesis
Aaron C Petrey et al.
Disease models & mechanisms, 5(2), 177-190 (2011-11-03)
The severe pediatric disorder mucolipidosis II (ML-II; also known as I-cell disease) is caused by defects in mannose 6-phosphate (Man-6-P) biosynthesis. Patients with ML-II exhibit multiple developmental defects, including skeletal, craniofacial and joint abnormalities. To date, the molecular mechanisms that

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