C3167
Corticotropin Releasing Factor sheep
≥95% (HPLC)
Synonym(s):
CRF, CRH
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About This Item
Empirical Formula (Hill Notation):
C205H339N59O63S
CAS Number:
Molecular Weight:
4670.31
MDL number:
UNSPSC Code:
12352200
NACRES:
NA.32
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Amino Acid Sequence
Ser-Gln-Glu-Pro-Pro-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Thr-Lys-Ala-Asp-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-Asn-Arg-Lys-Leu-Leu-Asp-Ile-Ala-NH2
Biochem/physiol Actions
CRF is a hypothalamic peptide that releases ACTH and endorphin from the anterior pituitary. It is also a neurotransmitter in the central nervous system, and is involved in autonomic and endocrine responses to stress.
Other Notes
Lyophilized from 0.1% TFA in H2O
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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Joshua J Wind et al.
The Journal of clinical endocrinology and metabolism, 98(6), 2285-2293 (2013-04-05)
It is often difficult to find an adenoma in patients with Cushing's disease (CD) whose preoperative magnetic resonance imaging (MRI) is normal. Better localizing modalities are needed. The aim of this study was to determine the accuracy of inferior petrosal
Neuroscience. Plasticity in the neurotransmitter repertoire.
Susan J Birren et al.
Science (New York, N.Y.), 340(6131), 436-437 (2013-04-27)
L O E Ebbesson et al.
Journal of neuroendocrinology, 23(8), 733-741 (2011-05-20)
Salmon parr-smolt transformation (smoltification) is a mid-life transitional stage between life in freshwater and seawater that entails a wide range of neural, endocrine and physiological modifications. In salmon, the neuroendocrine corticotropin-releasing factor (CRF) system regulates pituitary adrenocorticotrophic hormone and thyrotrophin
Cun Li et al.
Endocrinology, 154(7), 2365-2373 (2013-04-30)
Intrauterine growth restriction (IUGR) is an important fetal developmental problem resulting from 2 broad causes: maternal undernutrition and/or decreased fetal nutrient delivery to the fetus via placental insufficiency. IUGR is often accompanied by up-regulation of the hypothalamo-pituitary-adrenal axis (HPAA). Sheep
M J Dickens et al.
Journal of neuroendocrinology, 25(4), 329-339 (2012-12-21)
In the male brain, the medial preoptic nucleus (POM) is known to be a critical relay for the activation of sexual behaviour, with the aromatisation of testosterone into 17β-oestradiol (E2 ) playing a key role. Acute stress has been shown
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