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Sigma-Aldrich

(Trimethylsilyl)isocyanate

85%

Synonym(s):

Isocyanatotrimethylsilane

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About This Item

Linear Formula:
(CH3)3SiNCO
CAS Number:
1118-02-1
Molecular Weight:
115.21
Beilstein:
1744962
EC Number:
214-256-8
MDL number:
MFCD00001993
UNSPSC Code:
12352100
PubChem Substance ID:
24855227
NACRES:
NA.22

Assay

85%

form

liquid

impurities

<15% hexamethyldisiloxane

refractive index

n20/D 1.396 (lit.)

bp

90-92 °C (lit.)

density

0.851 g/mL at 25 °C (lit.)

SMILES string

C[Si](C)(C)N=C=O

InChI

1S/C4H9NOSi/c1-7(2,3)5-4-6/h1-3H3

InChI key

NIZHERJWXFHGGU-UHFFFAOYSA-N

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Application

Trimethylsilyl isocyanate was used in:
  • postsynthetic modification of isoreticular metal-organic framework-3
  • synthesis of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones
  • conversion of isocyanates to carbodiimides with cyclopentadienyl Fe(CO)2 or -Mn(CO)3 catalysis
  • carbamoylation of aromatic hydrocarbons and alcohols

Signal Word

Danger

Hazard Classifications

Acute Tox. 3 Inhalation - Eye Irrit. 2 - Flam. Liq. 2 - Resp. Sens. 1 - Skin Sens. 1 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

23.0 °F - closed cup

Flash Point(C)

-5 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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J. Prakt. Chem./Chem.-Ztg., 335, 558-558 (1993)
SiNCO+ and SiNCS+ and their neutral counterparts.
Srinivas R, et al.
Chemical Physics Letters, 316(3), 243-247 (2000)
Reactions of trimethylsilyl isocyanate and isothiocyanate with 3-(dialkylamino)-2H-azirines. A facile synthesis of 1-unsubstituted 4-(dialkylamino) imidazolin-2-ones and 4-(dialkylamino) imidazoline-2-thiones
Handke I, et al.
The Journal of Organic Chemistry, 53(22), 5298-5300 (1988)
Emily Dugan et al.
Chemical communications (Cambridge, England), (29)(29), 3366-3368 (2008-07-18)
Isoreticular metal-organic framework-3 (IRMOF-3) has been postsynthetically modified with isocyanates to generate unprecedented, microporous urea-functionalized frameworks.
S Manfredini et al.
Journal of medicinal chemistry, 37(15), 2401-2405 (1994-07-22)
As a continuation of previous studies on the synthesis and antitumor activity of geiparvarin analogues bearing a carbamate moiety in the alkyl side chain, a series of N-substituted [(E)-3-(4,5-dihydro-5,5-dimethyl-4-oxo-2-furanyl)-2- butenyl]carbamates (15a-f) were synthesized and tested with the objective to investigate
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