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244929

Sigma-Aldrich

Dichloro(ethylenediamine)platinum(II)

99%

Synonym(s):

Dichloro(1,2-diaminoethane)platinum, Dichloro(1,2-ethanediamine)platinum, Platinum ethylenediamine dichloride

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About This Item

Linear Formula:
(H2NCH2CH2NH2)PtCl2
CAS Number:
14096-51-6
Molecular Weight:
326.08
EC Number:
237-943-4
MDL number:
MFCD00000011
UNSPSC Code:
12161600
PubChem Substance ID:
24854717
NACRES:
NA.22

Assay

99%

form

solid

reaction suitability

core: platinum
reagent type: catalyst

SMILES string

Cl[Pt]Cl.NCCN

InChI

1S/C2H8N2.2ClH.Pt/c3-1-2-4;;;/h1-4H2;2*1H;/q;;;+2/p-2

InChI key

LMABILRJNNFCPG-UHFFFAOYSA-L

Related Categories

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H315,H319,H335

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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L C Perrin et al.
Anti-cancer drug design, 14(3), 243-252 (1999-09-29)
An in vitro transcription assay was used to probe the sequence specificity of the binding of phenazine-tethered platinum complexes to DNA. It was found that when compared to cis-dichloro(ethylenediamine)platinum(II), the number of RNA polymerase blockage sites was increased by approximately
R J Holmes et al.
Journal of inorganic biochemistry, 85(2-3), 209-217 (2001-06-19)
A series of intercalator-tethered platinum(II) complexes PtLCl(2) have been prepared where L are the diamine ligands N-[2-[(aminoethyl)amino]ethyl]-9-aminoacridine-4-carboxamide, N-[3-[(2-aminoethyl)amino]propyl]-9-aminoacridine-4-carboxamide, N-[4-[(2-aminoethyl)amino]butyl]-9-aminoacridine-4-carboxamide and N-[5-[(aminoethyl)amino]pentyl]-9-aminoacridine-4-carboxamide and N-[6-[(aminoethyl)amino]hexyl]-9-aminoacridine-4-carboxamide. The activity of the complexes was assessed in the CH-1, CH-1cisR, 41M, 41McisR and SKOV-3 cell lines.
S Isonishi et al.
British journal of cancer, 69(2), 217-221 (1994-02-01)
Sensitivity to platinum-containing drugs is believed to be a function of how much drug enters the cell, the extent of DNA adduct formation and the rate at which DNA is repaired. Activation of protein kinase C by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) was
A Eastman
Chemico-biological interactions, 61(3), 241-248 (1987-03-01)
Glutathione can modulate the toxicity of a variety of drugs, although its role in modulating toxicity by anticancer platinum drugs is ambivalent. At physiologically relevant concentrations, glutathione can inhibit the reaction between DNA and cis-dichloro(ethylenediamine)platinum(II) (cis-DEP). Glutathione can also react
E Kimura et al.
Cancer chemotherapy and pharmacology, 32(6), 419-424 (1993-01-01)
Expression of the heat-shock protein HSP-60 is associated with poor survival in patients with ovarian carcinoma. We examined both the nature of the interaction between hyperthermia and cisplatin (DDP) using the human ovarian carcinoma cell line 2008 and the effect
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