U1752

Uridine 5′-monophosphate

≥98%

• Synonym(s): U 5′-P, UMP, Uridylic acid
• Empirical Formula (Hill Notation): C₉H₁₃N₂O₉P
• CAS Number: 58-97-9
• Molecular Weight: 324.18
• EC Number: 200-408-0
• MDL number: MFCD00067346
• UNSPSC Code: 41106305
• PubChem Substance ID: 24900628
• NACRES: NA.51

Properties

• biological source: natural (organic)
• Assay: ≥98%
• form: powder
• solubility: H₂O: soluble 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: OC1C(O)C(OC1COP(O)(O)=O)N2C=CC(=O)NC2=O
• InChI: 1S/C9H13N2O9P/c12-5-1-2-11(9(15)10-5)8-7(14)6(13)4(20-8)3-19-21(16,17)18/h1-2,4,6-8,13-14H,3H2,(H,10,12,15)(H2,16,17,18)
• InChI key: DJJCXFVJDGTHFX-UHFFFAOYSA-N

Description

General description

Uridine 5′-monophosphate acts as a precursor for all pyrimidine nucleotides.

Application

Uridine 5′-monophosphate has been used as a component in isotonic E3 medium for isotonic reconstitution experiments to study its effects on the basal cell response or epithelial cell migration to the wound in the isotonic medium.

Biochem/physiol Actions

Uridine 5′-monophosphate (UMP) is a nucleotide monomer in RNA. It contains the nucleobase uracil along with the ribose sugar and a phosphate group. UMP dietary supplementation enhances neurotransmitter release and neurite outgrowth and also promotes membrane phosphatide production in adult rats. Oral supplementation of DHA, co-administered with UMP, in adult gerbils shows an increase in dendritic spines and neuronal membrane synthesis. It suggests a strategy for the treatment of cognitive disorders resulting from synapse loss.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves